Chloramphenicol acetyl transferase (CAT)-defective somatostatin fusion protein and uses thereof
First Claim
Patent Images
1. A composition comprising:
- a chimeric polypeptide comprising a somatostatin-14 polypeptide represented by SEQ ID NO;
1 and a chloramphenicol acetyl transferase polypeptide having a sequence selected from the group consisting of SEQ ID NO;
4, SEQ ID NO;
8, and SEQ ID NO;
9,wherein the composition is substantially endotoxin free.
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Abstract
Chimeric somatostatin-based polypeptides, polynucleotides used to encode the polypeptides, the methods for isolating and producing the polypeptides and the uses thereof are provided. In addition, low cost adjuvants for enhanced immunogenic response are provided. Vaccinations that include both chimeric somatostatin-based polypeptides and novel adjuvants are included, useful in facilitating farm animal productivity.
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Citations
17 Claims
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1. A composition comprising:
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a chimeric polypeptide comprising a somatostatin-14 polypeptide represented by SEQ ID NO;
1 and a chloramphenicol acetyl transferase polypeptide having a sequence selected from the group consisting of SEQ ID NO;
4, SEQ ID NO;
8, and SEQ ID NO;
9,wherein the composition is substantially endotoxin free. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A composition comprising:
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a chimeric polypeptide comprising a somatostatin-14 polypeptide represented by SEQ ID NO;
1 and a chloramphenicol acetyl transferase polypeptide,wherein the chloramphenicol acetyl transferase polypeptide is modified at the 192 residue, at the 193 residue, or at both 192 and 193 residues, relative to the wild type chloramphenicol acetyl transferase polypeptide represented by residues 1-210 of SEQ ID NO;
15, andwherein the modification comprises replacement of one or both histidines independently with glycine or alanine. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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Specification