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In vitro sorting method

  • US 8,367,326 B2
  • Filed: 06/21/2007
  • Issued: 02/05/2013
  • Est. Priority Date: 07/07/1997
  • Status: Expired due to Fees
First Claim
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1. A method for screening a compound or compounds capable of modulating the activity of a gene product, comprising the steps of:

  • (a) preparing a repertoire of genetic elements encoding the gene product;

    (b) expressing the genetic elements to produce their respective gene products and linking the gene products to the genetic elements encoding them;

    (c) compartmentalizing the genetic elements into microcapsules;

    (d) sorting the genetic elements which produce the gene product(s) having a desired activity; and

    (e) contacting a gene product having the desired activity with the compound or compounds and monitoring the modulation of an activity of the gene product by the compound or compounds.

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