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Hydrogels with covalent and noncovalent crosslinks

  • US 8,367,639 B2
  • Filed: 06/14/2010
  • Issued: 02/05/2013
  • Est. Priority Date: 03/31/2005
  • Status: Expired due to Fees
First Claim
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1. A hydrogel comprising a matrix, the matrix comprising a cross-linking structure selected from the group consisting of(A) PEG-LMWH-PEG,(B) PEG-LMWH-HBC-LMWH-PEG,(C) PEG-LMWH-HBC-PEG*-HBC-LMWH-PEG,(D) PEG-LMWH-PEG-HBC, and(E) LMWH-PEG-HBC-PEG*;

  • wherein the hydrogel further comprises a natural or synthetic polymer;

    wherein the PEG in a PEG-LMWH conjugate or in a LMWH-PEG conjugate is covalently bound to the LMWH, and is covalently bound to the polymer, and is branched or unbranched;

    wherein the HBC is bound to the LMWH molecule by a covalent bond or a non-covalent bond, or wherein the HBC is covalently bound to the PEG molecule in the PEG-LMWH conjugate, or wherein the HBC is covalently bound to a PEG* molecule, wherein the PEG* molecule is a PEG molecule that is not covalently attached to the LMWH, and wherein the PEG* molecule is branched or unbranched.

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