Peritoneal dialysis fluid

• US 8,367,731 B2
• Filed: 05/03/2006
• Issued: 02/05/2013
• Est. Priority Date: 05/30/2005
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius SE & Co. KGaA)
• Original Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius SE & Co. KGaA)
• Inventors: Wieslander, Anders, Carlsson, Ola, Kjellstrand, Per, Braide, Magnus
• Primary Examiner(s): Padmanabhan, Sreeni
• Assistant Examiner(s): Betton, Timothy E
• Application Number:
  US11/921,224
• Publication Number:
  US 20090306211A1
• Time in Patent Office: 2,470 Days
• Field of Search: 514/183
• US Class Current: 514/574
• CPC Class Codes: A61K 31/194 having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61P 7/08 Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock artificial tears A61P27/04

Abstract

The present invention concerns a peritoneal dialysis fluid with enhanced ultrafiltration during the dialysis dwell period. According to the present invention this is achieved by a peritoneal dialysis fluid comprising sodium ions, osmotic agent and a buffer, characterised in that it comprises citrate at a level of 4 to 10 mM in a final solution ready for use.

Claims

1. A peritoneal dialysis fluid comprising sodium ions, an osmotic agent, and a buffer, the peritoneal dialysis fluid further including citrate at a concentration of 4 to 10 mM in a final solution, said final solution being ready for use.

2. The peritoneal dialysis fluid according to claim 1, wherein the citrate is present at a concentration of 5-9 mM in the final solution.

3. The peritoneal dialysis fluid according to claim 1, wherein the citrate is present at a concentration of 7-8 mM in the final solution.

4. The peritoneal dialysis fluid according to claim 1, wherein the peritoneal dialysis fluid includes 1-10% by weight of the osmotic agent, 90-140 mM sodium ions, and 0.0-1.75 mM calcium ions in the final solution.

5. The peritoneal dialysis fluid according to claim 1, wherein the osmotic agent is selected from the group consisting of glucose, polymers of glucose, amino sugars, essential and non-essential amino acids, and N-acetyl glucose amine (NAG).

6. The peritoneal dialysis fluid according to claim 1, wherein the peritoneal dialysis fluid includes, as a buffer, bicarbonate, lactate, or bicarbonate and lactate in a total concentration of 5-28 mM in the final solution.

7. The peritoneal dialysis fluid according to claim 1, including 1.5-4% by weight of glucose as the osmotic agent in the final solution.

8. The peritoneal dialysis fluid according to claim 1, including 5-10% by weight of glucose polymer as the osmotic agent in the final solution.

9. The peritoneal dialysis fluid according to claim 1, including 1.5-4% by weight of N-acetyl glucose amine (NAG) as the osmotic agent in the final solution.