Silicone hydrogel contact lens

• US 8,367,746 B2
• Filed: 09/20/2006
• Issued: 02/05/2013
• Est. Priority Date: 08/27/2004
• Status: Active Grant

• Current Assignee: Coopervision International Limited (The Cooper Cos., Inc.)
• Original Assignee: Coopervision International Holding Company LP (The Cooper Cos., Inc.)
• Inventors: Manesis, Nick J., Back, Arthur
• Primary Examiner(s): PEPITONE, MICHAEL F
• Application Number:
  US11/525,106
• Publication Number:
  US 20070066706A1
• Time in Patent Office: 2,330 Days
• Field of Search: 523/106, 523/107, 523/108, 351/160.H, 351/160.R, 351/159.02, 351/159.33, 424/429
• US Class Current: 523/106
• CPC Class Codes: C08L 51/085 on to polysiloxanes
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

Silicone hydrogel contact lenses are provided which have reduced modulus and contact angle properties, and which have acceptable wettabilities for use in daily wear and extended or continuous wear applications.

Claims

1. A contact lens comprising:

a soft lens body having an anterior surface and a posterior surface at least one of which is not surface treated, the lens body comprising at least one hydrophilic silicon-containing polymeric material and having a water content of at least about 30% by weight, a contact angle hysteresis of less than 15° and

a modulus of less than about 0.8 MPa, wherein the contact angle hysteresis is the difference between an advancing contact angle of the lens body and a receding contact angle of the lens body.

2. The contact lens of claim 1 which is a silicone hydrogel contact lens.

3. The contact lens of claim 1, wherein the lens body has an advancing contact angle of about 70°

or less.

4. The contact lens of claim 1, wherein the lens body has an advancing contact angle of about 60°

or less.

5. The contact lens of claim 1, wherein the lens body has a contact angle hysteresis of less than 13°

.

6. The contact lens of claim 1, wherein the lens body has an oxygen permeability, a water content, a surface wettability, a modulus, and a design effective in facilitating ophthalmically compatible wearing of the contact lens by the lens wearer at least for one day.

7. The contact lens of claim 1, wherein the lens body has an oxygen permeability, a water content, a surface wettability, a modulus, and a design effective in facilitating ophthalmically compatible wearing of the contact lens by the lens wearer for about thirty days.

8. The contact lens of claim 1, wherein the lens body has an oxygen permeability of at least about 50 barrers.

9. The contact lens of claim 1, wherein the lens body has an oxygen permeability of at least about 120 barrers.

10. The contact lens of claim 1, wherein both the anterior and posterior surfaces are not surface treated.

11. The contact lens of claim 1, wherein the lens body has an ionoflux of no greater than about 5 10⁻

3 mm²/min.

32. The contact lens of claim 1, wherein the sum of the advancing contact angle and the receding contact angle of the lens body is in a range of more than 94°

to less than 117°

.

33. The contact lens of claim 1, wherein the lens body results in corneal staining incidences of less than about 30% after the contact lens is continuously worn during an overnight sleep, based on a representative population of lens wearers.

34. The contact lens of claim 1, wherein the lens body is a polymerized reaction product of a precursor composition consisting essentially of copolymerizable monomers.

12. A contact lens comprising:

a soft lens body having an anterior surface and a posterior surface at least one of which is not surface treated, the lens body comprising at least one hydrophilic silicon-containing polymeric material and having a water content of at least about 30% by weight, a receding contact angle of 49°

or less, a contact angle hysteresis of 45°

or less, and a modulus of less than about 0.8 MPa, wherein the contact angle hysteresis of the lens body is the difference between an advancing contact angle of the lens body and the receding contact angle of the lens body.

13. The contact lens of claim 12, which is a silicone hydrogel contact lens.

14. The contact lens of claim 12, wherein the contact angle hysteresis of the lens body is about 30°

or less.

15. The contact lens of claim 12, wherein the lens body has an oxygen permeability, a water content, a surface wettability, a modulus, and a design effective in facilitating ophthalmically compatible wearing of the contact lens by the lens wearer at least for one day.

16. The contact lens of claim 12, wherein the lens body has an oxygen permeability, a water content, a surface wettability, a modulus, and a design effective in facilitating ophthalmically compatible wearing of the contact lens by the lens wearer for about thirty days.

17. The contact lens of claim 12, wherein the lens body has an oxygen permeability of at least about 50 barrers.

18. The contact lens of claim 12, wherein the lens body has an oxygen permeability of at least about 120 barrers.

19. The contact lens of claim 12, wherein both the anterior and posterior surfaces are not surface treated.

35. The contact lens of claim 12, wherein the sum of the advancing contact angle and the receding contact angle being in a range of more than 94°

to less than 117°

.

36. The contact lens of claim 12, wherein the lens body results in corneal staining incidences of less than about 30% after the contact lens is continuously worn during an overnight sleep, based on a representative population of lens wearers.

37. The contact lens of claim 12, wherein the lens body is a polymerized reaction product of a precursor composition consisting essentially of copolymerizable monomers.

20. A contact lens comprising:

a soft lens body having an anterior surface and a posterior surface which are not surface treated, the lens body comprising at least one hydrophilic silicon-containing polymeric material and having a water content of at least about 30% by weight, a modulus less than 1 MPa, an advancing contact angle and a receding contact angle, the sum of the advancing contact angle and the receding contact angle being in a range of more than 94°

to less than 117°

, and a contact angle hysteresis of less than 30°

, wherein the contact angle hysteresis is the difference between an advancing contact angle of the lens body and a receding contact angle of the lens body.

21. The contact lens of claim 20 which is a silicone hydrogel lens.

22. The contact lens of claim 20, wherein the sum of the advancing contact angle and the receding contact angle is in a range of 95°

to 115°

.

23. The contact lens of claim 20, wherein the sum of the advancing contact angle and the receding contact angle is about 110°

or less.

24. The contact lens of claim 20, wherein the contact angle hysteresis is less than 20°

.

25. The contact lens of claim 20, wherein the advancing contact angle is less than about 90°

.

26. The contact lens of claim 20, wherein the advancing contact angle is less than about 65°

.

27. The contact lens of claim 20, wherein the lens body has an oxygen permeability, a water content, a surface wettability, a modulus, and a design effective in facilitating ophthalmically compatible wearing of the contact lens by the lens wearer at least for one day.

28. The contact lens of claim 20, wherein the lens body has an oxygen permeability, a water content, a surface wettability, a modulus, and a design effective in facilitating ophthalmically compatible wearing of the contact lens by the lens wearer for about thirty days.

29. The contact lens of claim 20, wherein the lens body has an oxygen permeability of at least about 50 barrers.

30. The contact lens of claim 20, wherein the lens body has an oxygen permeability of at least about 120 barrers.

31. The contact lens of claim 20, wherein the lens body has a modulus less than about 0.8 MPa.

38. The contact lens of claim 20, wherein the lens body results in corneal staining incidences of less than about 30% after the contact lens is continuously worn during an overnight sleep, based on a representative population of lens wearers.

39. The contact lens of claim 20, wherein the lens body is a polymerized reaction product of a precursor composition consisting essentially of copolymerizable monomers.