Ocular implant architectures

• US 8,372,026 B2
• Filed: 02/03/2012
• Issued: 02/12/2013
• Est. Priority Date: 09/24/2007
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Ivantis Inc.
• Inventors: Schieber, Andrew T., Euteneuer, Charles L.
• Primary Examiner(s): Matthews, William H.
• Application Number:
  US13/366,073
• Publication Number:
  US 20120136439A1
• Time in Patent Office: 375 Days
• Field of Search: 604/8, 604/9, 604/289, 604/294, 623 511- 513
• US Class Current: 604/8
• CPC Class Codes: A61F 2/14 Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 5/00 Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests vaccination appliances for veterinary use A61D1/025 ; tube connectors, tube couplings, valves or branch units specially adapted for medical use A61M39/00; containers specially adapted for medical or pharmaceutical purposes A61J1/00; combinations of vial and syringe for mixing or transferring their contents A61J1/20; holders for containers for collecting, storing or administering blood or medical fluids A61J1/16

Abstract

An ocular implant having a first spine; a second spine; a first strut extending in an axial direction Z between the first spine and the second spine; a second strut extending in an axial direction Z between the first spine and the second spine; wherein an angular dimension θ of a first edge of each strut undulates as the strut extends in the axial direction Z between the first spine and the second spine; and wherein a radius r of an outer surface of each strut remains substantially constant as the strut extends the axial direction Z between the first spine and the second spine.

Claims

1. An ocular implant comprising an inlet portion and a Schlemm'"'"'s canal portion distal to the inlet portion, the inlet portion being disposed at a proximal end of the implant and sized and configured to be placed within an anterior chamber of a human eye, the inlet portion having an inlet adapted to be in fluid communication with the anterior chamber, the Schlemm'"'"'s canal portion having a diameter between 0.005 inches and 0.04 inches, the Schlemm'"'"'s canal portion comprising:

a central channel in fluid communication with the inlet, the central channel extending longitudinally in a Z direction;

a first spine disposed along the central channel and having edges partially defining a first opening in fluid communication with the central channel;

a second spine disposed along the central channel and having edges partially defining the first opening, the second spine being disposed distal to the first spine;

a first frame disposed along the central channel distal to the first spine and proximal to the second spine;

a second frame disposed along the central channel distal to the second spine;

the first and second frames each comprising first and second struts, the first and second struts each having a first edge partially defining the first opening, the first edges of the first and second struts each having a circumferential extent around the central channel that undulates as the strut extends in the Z direction;

the spines and frames being arranged and configured to be disposed within Schlemm'"'"'s canal of the eye when the inlet is disposed in the anterior chamber.

2. The implant of claim 1 wherein the circumferential extent of the first edges of each strut is greater than a circumferential extent of the first spine and is greater than a circumferential extent of the second spine.

3. The implant of claim 1 wherein a radius r of each strut measured from a central longitudinal axis extending in the Z direction of the implant is constant along the Z direction of the strut.

4. The implant of claim 1 wherein an angular dimension θ

of the first edge of each strut measured from a central longitudinal axis extending in the Z direction of the implant varies as the strut extends in the Z direction.

5. The implant of claim 4 wherein the angular dimension θ

varies between 82° and

142°

as the strut extends in the Z direction.

6. The implant of claim 5 wherein the angular dimension θ

varies between 82° and

142°

over a Z distance of 432 micrometers.

7. The implant of claim 1 wherein the ocular implant has a generally curved at rest shape.

8. The implant of claim 7 wherein the first opening faces radially outward from the curved shape.

9. The implant of claim 8 wherein each spine comprises a surface facing the central channel and facing radially outward from the curved shape.

10. The implant of claim 1 wherein the Schlemm'"'"'s canal portion of the ocular implant has a length adapted to extend greater than or equal to 60°

and less than or equal to 180°

around a circumference of Schlemm'"'"'s canal of a human eye.

11. An ocular implant comprising an inlet portion and a Schlemm'"'"'s canal portion distal to the inlet portion, the inlet portion being disposed at a proximal end of the implant and sized and configured to be placed within an anterior chamber of a human eye, the inlet portion having an inlet adapted to be in fluid communication with the anterior chamber, the Schlemm'"'"'s canal portion having a diameter between 0.005 inches and 0.04 inches, the Schlemm'"'"'s canal portion comprising:

a central channel in fluid communication with the inlet, the central channel extending longitudinally in a Z direction;

a first spine disposed along the central channel and having edges partially defining a first opening in fluid communication with the central channel;

a second spine disposed along the central channel and having edges partially defining the first opening, the second spine being disposed distal to the first spine;

a first frame disposed along the central channel distal to the first spine and proximal to the second spine;

a second frame disposed along the central channel distal to the second spine;

the first and second frames each comprising first and second struts, the first and second struts each having a first edge partially defining the first opening, the first edges of the first and second struts each having a circumferential extent around the central channel that varies long the extent of the strut in the Z direction;

the spines and frames being arranged and configured to be disposed within Schlemm'"'"'s canal of the eye when the inlet is disposed in the anterior chamber.

12. The implant of claim 11 wherein the circumferential extent of the first edges of each strut is greater than a circumferential extent of the first spine and is greater than a circumferential extent of the second spine.

13. The implant of claim 11 wherein a radius r of each strut measured from a central longitudinal axis extending in the Z direction of the implant is constant along a Z direction of the strut.

14. The implant of claim 11 wherein an angular dimension θ

of the first edge of each strut measured from a central longitudinal axis extending in the Z direction of the implant varies continuously as the strut extends in the Z direction.

15. The implant of claim 14 wherein the angular dimension θ

varies between 82° and

142°

as the strut extends in the Z direction.

16. The implant of claim 15 wherein the angular dimension θ

varies between 82° and

142°

over a Z distance of 432 micrometers.

17. The implant of claim 11 wherein the ocular implant has a generally curved at rest shape.

18. The implant of claim 17 wherein the first opening faces radially outward from the curved shape.

19. The implant of claim 18 wherein each spine comprises a surface facing the central channel and facing radially outward from the curved shape.

20. The implant of claim 11 wherein the Schlemm'"'"'s canal portion of the ocular implant has a length adapted to extend greater than or equal to 60°

and less than or equal to 180°

around a circumference of Schlemm'"'"'s canal of a human eye.