Implantable artificial ventricle having low energy requirement

• US 8,372,145 B2
• Filed: 08/28/2009
• Issued: 02/12/2013
• Est. Priority Date: 05/19/2009
• Status: Active Grant

• Current Assignee: Hisham M.F. Sherif
• Original Assignee: Hisham M.F. Sherif
• Inventors: Sherif, Hisham M. F.
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): PRESTON, REBECCA STRASZHEIM
• Application Number:
  US12/549,561
• Publication Number:
  US 20100298932A1
• Time in Patent Office: 1,264 Days
• Field of Search: None
• US Class Current: 623/3.17
• CPC Class Codes: A61M 2205/0283 Electro-active polymers [EAP]
• CPC Class Codes: A61M 60/148 in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• CPC Class Codes: A61M 60/165 implantable in, on, or around the heart
• CPC Class Codes: A61M 60/178 drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
• CPC Class Codes: A61M 60/268 the displacement member being flexible, e.g. membranes, diaphragms or bladders
• CPC Class Codes: A61M 60/454 generated by electro-active actuators, e.g. using electro-active polymers or piezoelectric elements
• CPC Class Codes: A61M 60/869 Compliance chambers containing a gas or liquid other than blood to compensate volume variations of a blood chamber
• CPC Class Codes: A61M 60/871 Energy supply devices; Converters therefor
• CPC Class Codes: A61M 60/894 Passive valves, i.e. valves actuated by the blood
• CPC Class Codes: A61M 60/896 having flexible or resilient parts, e.g. flap valves

Abstract

A pulsatile, positive-displacement mechanical circulatory support pump which can be used for assistance or replacement of one or both ventricles. The pump includes a plurality of contractile elements radiating outward from an apex of a compliance chamber, the elements being incorporated in and/or in contact with at least a portion of an outer surface of the compliance chamber. These contractile elements include an electroactive dielectric elastomer or an ion exchange membrane metallic composite. Application of electric field pulses from an implantable electrical energy source such as a pacemaker will cause the contractile elements to compress and expand the compliance chamber.

Claims

1. An artificial ventricle, comprising:

(A) a pulsatile, positive-displacement blood pump comprising a biologically inert housing containing;

a hollow, flexible compliance chamber,

an inlet valve for said compliance chamber, said inlet valve adapted to be operatively connected to a patient'"'"'s ventricular apex or atrial wall,

an outlet valve for said compliance chamber, said outlet valve adapted to be operatively connected to the patient'"'"'s aorta or pulmonary artery;

a plurality of contractile elements radiating outward from an apex of said compliance chamber, said contractile elements being incorporated in and/or in contact with at least a portion of an outer surface of said compliance chamber, said contractile elements comprising an electroactive dielectric elastomer or an ion exchange membrane metallic composite, said contractile elements operatively connected to a common electrode, and

(B) an implantable energy source operatively connected to said common electrode,

wherein said electroactive dielectric elastomer is a member of the group consisting of polyaniline elastomers, polysulfone elastomers, polyacetylene elastomers, polypyrrole elastomers, polyvinylidene difluoride elastomers, silicone elastomers, and acrylic elastomers.

2. The artificial ventricle of claim 1, wherein said inlet valve comprises a cylindrical channel in communication with said compliance chamber, said channel containing a one-way valve selected from the group consisting of a ball check valve, a Gott valve, and a tri-leaflet pericardial valve.

3. The artificial ventricle of claim 1, wherein said outlet valve comprises a cylindrical channel in communication with said compliance chamber, said channel containing a one-way valve selected from the group consisting of a ball check valve, a Gott valve, and a tri-leaflet pericardial valve.

4. The artificial ventricle of claim 1, wherein said inlet and outlet valves are located at a base of said housing, with said inlet and outlet valves arranged at an angle of 90 to 120°

to one another.

5. The artificial ventricle of claim 1, wherein said compliance chamber is made of polyester fabric or polytetrafluoroethylene fabric.

6. The artificial ventricle of claim 5, wherein said polyester fabric or polytetrafluoroethylene fabric has external ridges helically arranged about a longitudinal axis of said compliance chamber.

7. The artificial ventricle of claim 5, wherein said polyester fabric comprises polyethylene terephthalate coated with collagen.

8. The artificial ventricle of claim 5, wherein said polyester or polytetrafluoroethylene polyester comprises knitted double velour fabric or woven double velour fabric.

9. The artificial ventricle of claim 1, wherein said compliance chamber has an internal volume of 20-80 ml.

10. The artificial ventricle of claim 9, wherein said compliance chamber has a height of 4-10 cm and a diameter of 4-8 cm.

11. The artificial ventricle of claim 1, wherein said compliance chamber has a shape of a dome.

12. The artificial ventricle of claim 1, wherein said compliance chamber has a curved cylindrical shape, with said inlet and outlet valves located at opposite ends of said compliance chamber.

13. The artificial ventricle of claim 1, wherein said contractile elements comprise an electroactive dielectric elastomer, and said electroactive dielectric elastomer is an acrylic elastomer.

14. The artificial ventricle of claim 1, wherein said contractile elements comprise an ion exchange membrane metallic composite, and said ion exchange membrane metallic composite comprises perfluorocarboxylate-gold or sulfonated poly(styrene-ethylene-butylene-styrene).

15. The artificial ventricle of claim 1, wherein two or more of said contractile elements are inter-connected at a point other than said apex.

16. The artificial ventricle of claim 1, wherein said contractile elements are arranged helically.

17. The artificial ventricle of claim 1, further comprising additional contractile elements arranged circumferentially around a base of said compliance chamber.

18. The artificial ventricle of claim 1, wherein said housing has the shape of a truncated dome.

19. The artificial ventricle of claim 1, wherein said housing is made of titanium or polyurethane.

20. The artificial ventricle of claim 1, further comprising a common voltage regulator operatively connected between said electrode and said plurality of contractile elements.

21. The artificial ventricle of claim 1, wherein said implantable energy source comprises a pacemaker.

22. The artificial ventricle of claim 1, wherein said contractile elements are in elongated or strip form.