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Multiple coagulation test cartridge and method of using same

  • US 8,372,343 B2
  • Filed: 12/07/2007
  • Issued: 02/12/2013
  • Est. Priority Date: 12/07/2007
  • Status: Active Grant
First Claim
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1. A system for determining an appropriate coagulation therapy for a patient, comprising:

  • a multiple coagulation test system comprising a holder for containing the patient'"'"'s blood, one or more coagulation detectors, multiple test wells, and multiple ports in fluid communication with the test wells;

    a disposable, single-use cartridge, which prior to use in evaluating the patient'"'"'s blood, comprises;

    multiple containers, wherein each container includes;

    a potential coagulation therapy for administering to the patient, each potential coagulation therapy including one or more coagulants or anticoagulants in an amount suitable for use with evaluating blood clotting in a single patient to determine whether the potential coagulation therapy is appropriate for the patient; and

    a deformable seal at at least one end of the container;

    the cartridge configured to be coupled with the multiple coagulation test system, in which the cartridge has a first configuration prior to the cartridge being coupled with the multiple coagulation test system, in which the containers are sealed by the deformable seals, and a second configuration after the cartridge is coupled with the multiple coagulation test system, in which the containers are unsealed and in fluid communication with the ports of the multiple coagulation test system so the potential coagulation therapies in the containers may be released from the containers into the test wells of the multiple coagulation test system to allow for evaluation of clotting of the patient'"'"'s blood with the potential coagulation therapies by the multiple coagulation test system; and

    wherein each of the potential coagulation therapies includes a different coagulant, anticoagulant or combination thereof as compared to another of the potential coagulation therapies; and

    wherein at least one of the containers includes multiple volumes that are separated from each other by one or more membranes and the potential coagulation therapy contained in the at least one container includes a different coagulant or anticoagulant of the potential therapy in each of the multiple volumes, and wherein each of the multiple volumes is in fluid communication with at least one port of the multiple coagulation test system when the cartridge is in the second configuration.

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