Lactobacillus paracasei strain LT12 as immunity regulatory agent

• US 8,372,392 B2
• Filed: 12/23/2009
• Issued: 02/12/2013
• Est. Priority Date: 12/23/2009
• Status: Active Grant

• Current Assignee: Lytone Enterprise, Inc.
• Original Assignee: Lytone Enterprise, Inc.
• Inventors: Chang, William Tien Hung, Wang, Yi Chieh, Li, Shu Ling
• Primary Examiner(s): Zeman, Robert A
• Application Number:
  US12/646,275
• Publication Number:
  US 20110150838A1
• Time in Patent Office: 1,147 Days
• Field of Search: None
• US Class Current: 424/93.45
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/3204 Probiotics, living bacteria to be ingested for action in the digestive tract
• CPC Class Codes: A23V 2200/324 having an effect on the immune system
• CPC Class Codes: A61K 35/74 Bacteria therapeutic use of a bacterial protein A61K38/00
• CPC Class Codes: A61P 11/02 Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 27/14 Decongestants or antiallergics
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C12N 1/20 Bacteria; Culture media therefor
• CPC Class Codes: C12N 1/205 Bacterial isolates
• CPC Class Codes: C12R 2001/225 Lactobacillus

Abstract

An isolated Lactobacillus paracasei strain LT12 and its genetically-engineered variant that possesses immune regulating activity and uses thereof for regulating immune responses and treating allergy.

Claims

1. An isolated Lactobacillus paracasei strain, wherein the Lactobacillus paracasei strain is LT12 deposited with the Agricultural Research Culture Collection as Deposit Number NRRL-B50327.

2. A composition comprising the Lactobacillus paracasei strain LT12 of claim 1.

3. The composition of claim 2, wherein the Lactobacillus paracasei LT12 strain is viable.

4. The composition of claim 2, wherein the Lactobacillus paracasei strain LT12 is inactivated.

5. The composition of claim 2, which is a food product, a drink, or a medicament.