Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging
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Abstract
Compounds and methods related to NIR molecular imaging, in-vitro and in-vivo functional imaging, therapy/efficacy monitoring, and cancer and metastatic activity imaging. Compounds and methods demonstrated pertain to the field of peripheral benzodiazepine receptor imaging, metabolic imaging, cellular respiration imaging, cellular proliferation imaging as targeted agents that incorporate signaling agents.
20 Citations
15 Claims
- 1. A compound of the following formula:
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4. A method of imaging a molecular event in a sample, comprising:
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(a) administering to said sample a probe having an affinity for a target, the probe comprising at least one of a ligand/signaling agent combination, or conjugable form of said ligand/signaling agent combination; and (b) detecting a signal from said probe; wherein said ligand is a compound of the following formula; - View Dependent Claims (5, 6, 7, 8, 9, 10, 12, 13, 14, 15)
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Specification