Method and apparatus for the detection of aberrant neural-electric activity

• US 8,374,703 B2
• Filed: 01/26/2009
• Issued: 02/12/2013
• Est. Priority Date: 01/26/2009
• Status: Expired due to Fees

• Current Assignee: InCube Labs LLC. (In-Cube, Inc.)
• Original Assignee: InCube Labs LLC. (In-Cube, Inc.)
• Inventors: Imran, Mir
• Primary Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US12/359,830
• Publication Number:
  US 20100191305A1
• Time in Patent Office: 1,478 Days
• Field of Search: 607/116, 607/128, 607/119
• US Class Current: 607/116
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/30 Input circuits therefor
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

Embodiments provide an apparatus and method for detection of aberrant neural-electric activity (ANEA) in the brain causing an epileptic seizure or other neurologic condition. One embodiment provides an apparatus for detection of ANEA comprising an introducer having at least one lumen. The introducer is introduced into brain tissue through an opening in the skull. A reference electrode is positioned at an introducer distal portion. A plurality of electrode members are advanceable within the at least one lumen with each member having an insulated portion and an exposed distal portion. The members have a non-deployed state in the introducer and a deployed state when outwardly advanced out of the introducer. In the deployed state, the members are substantially orthogonal to each other with the exposed distal portions defining a detection volume capable of determining an electric field vector produced by the ANEA and the direction of a foci of the ANEA.

Claims

1. An apparatus for detection of aberrant neural-electric activity in a brain, the apparatus comprising:

an introducer having a proximal end and a distal end, and a plurality of lumens with a port coupled to each lumen, the ports positioned at the distal end of the introducer, the proximal end configured to be coupled to an electrical connector,

a reference electrode positioned at the distal end of the introducer; and

three electrode members advanceable within the plurality of lumens;

wherein each of the electrode members has an insulated proximal portion and an exposed distal portion, each electrode member having a non-deployed state and a

deployed state, the exposed distal portion of each electrode member being structured to have a bend when each electrode member is in the deployed state;

wherein when the electrode members are in the deployed state, the electrode members are substantially orthogonal to each other, and the bend of the electrode member is such that the exposed distal portions define a detection volume; and

wherein each electrode member defines a different axis of a Cartesian coordinate system with an origin at the distal end of the introducer wherein the electrode members are configured to detect a direction of a focus of the aberrant neural electric activity based on the detection volume.

2. The apparatus of claim 1, further comprising a plug configured to be inserted into a burr hole in the skull, the plug having lumen for insertion of the introducer.

3. The apparatus of claim 1, further comprising a processor configured to predict an epileptic seizure based on the direction of the focus of the aberrant neural-electric activity.

4. The apparatus of claim 3, wherein the processor is capable of determining, based on the direction of the focus, an electric field vector generated by the aberrant neural-electric activity.

5. The apparatus of claim 1, wherein the ports are spatially arranged to achieve the orthogonal relationship between the electrode members.

6. The apparatus of claim 1, wherein the electrode members comprise a shape memory material.

7. The apparatus of claim 1, wherein the reference electrode is positioned at a distal end of the introducer.

8. The apparatus of claim 1, wherein the electrode members have a stiffness configured to be advanced into brain tissue and maintain their bend.

9. The apparatus of claim 1, wherein the stiffness of the electrode members is configured to substantially maintain a size and shape of the detection volume after the electrode members are advanced into brain tissue.

10. The apparatus of claim 1, wherein the stiffness of the electrode members and their shape in the deployed state are configured to maintain a position of the electrode members in brain tissue.

11. The apparatus of claim 1, wherein the stiffness of the electrode members is configured to substantially maintain a size of the detection volume after the electrode members are advanced into the brain tissue.

12. The apparatus of claim 1, wherein a stiffness of the electrode members and their shape in the deployed state are configured to substantially anchor and/or stabilize a position of the electrode members in brain tissue.

13. The apparatus of claim 1, wherein a size and shape of the electrode members in the deployed state are configured to have a minimal physiologic effect on brain tissue in which they are deployed.

14. The apparatus of claim 1, wherein a conductive surface area of the electrode members has minimal effect on neural-electric activity of the brain.

15. The apparatus of claim 1, wherein a length of an electrode member adapted to be advanced into tissue is from about 0.5 cm to about 1.5 cm.