Process for transient and steady state delivery of biological agents to the lung via breathable liquids
First Claim
1. A method of delivering a biological agent in a breathable liquid to a lung of a patient via a liquid ventilation system comprising a ventilator circuit, the method comprising the steps of:
- mixing the biological agent with a breathable liquid substantially equal in volume to an initial filling volume of the lung to create a substantially homogeneous therapeutic mixture;
filling the lung with the therapeutic mixture;
establishing a steady state ventilation that circulates the therapeutic mixture in the lung and the ventilator circuit; and
adding additional biological agent to the ventilator circuit to maintain a substantially stable concentration of the biological agent in the lung.
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Abstract
The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering a biological agent in a breathable liquid to a lung of a patient. The steps of both the transient delivery method and the steady state delivery method can be controlled by a servo-control unit. A supplementary biological agent delivery step can be performed in both the transient method of delivering a biological agent and the steady state method of delivering a biological agent.
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Citations
19 Claims
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1. A method of delivering a biological agent in a breathable liquid to a lung of a patient via a liquid ventilation system comprising a ventilator circuit, the method comprising the steps of:
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mixing the biological agent with a breathable liquid substantially equal in volume to an initial filling volume of the lung to create a substantially homogeneous therapeutic mixture; filling the lung with the therapeutic mixture; establishing a steady state ventilation that circulates the therapeutic mixture in the lung and the ventilator circuit; and adding additional biological agent to the ventilator circuit to maintain a substantially stable concentration of the biological agent in the lung. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A servo-controlled method of delivering a biological agent in a breathable liquid to a lung of a patient via a liquid ventilation system comprising a ventilator circuit comprising a piping network, the method comprising the steps of:
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mixing, the biological agent with a breathable liquid substantially equal in volume to an initial filling volume of the lung to create a substantially homogeneous therapeutic mixture; passing the therapeutic mixture through the piping network to till the lung with the therapeutic mixture; establishing a steady state ventilation that circulates the therapeutic mixture in the lung and the ventilator circuit, the steady state ventilation comprising; a tidal volume from about 10 to about 20 ml/kg, an inspiratory time from about 3 to about 7 seconds, an expiratory time from about 8 to about 15 seconds, an inspiratory;
expiratory timing ratio value from about 1;
2 to about 1;
3,a breathing rate from about 3 to about 8 breaths per minute, an inspiratory flow rate from about 200 to about 280 rill/sec/kg, and an expiratory flow rate from about 20 to about 60 ml/sec/kg; and
adding additional biological agent to the ventilator circuit to maintain a substantially stable concentration of the biological agent in the lung. - View Dependent Claims (19)
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Specification