Implantable medical device coatings with improved mechanical stability

• US 8,377,116 B2
• Filed: 03/20/2008
• Issued: 02/19/2013
• Est. Priority Date: 03/20/2008
• Status: Expired due to Fees

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories), Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Hsu, Shaw Ling, Tang, Yiwen, Kleiner, Lothar W., Tang, Fuh-Wei, Ding, Ni, Hossainy, Syed Faiyaz Ahmed
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): Mathew, Seema
• Application Number:
  US12/052,452
• Publication Number:
  US 20090240325A1
• Time in Patent Office: 1,797 Days
• Field of Search: 623/1, 623/1.11, 623/1.15, 623/1.44, 623/1.46
• US Class Current: 623/1.46
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The present invention provides an implantable medical device coating that has improved stability, a medical device coated with such coating, and a method of increasing the stability of an implantable medical device coating, wherein the coating comprises a stereocomplex f poly(D-lactic acid) and poly(L-lactice acid).

Claims

1. An implantable medical device comprising:

a device body; and

a coating disposed over the device body, wherein the coating comprises a reservoir layer and further comprises a primer layer or a topcoat,

wherein the primer layer or the topcoat comprises a stereocomplex of poly(D-lactic acid) and poly(L-lactic acid).

2. The implantable medical device according to claim 1, wherein the device body comprises a stent.

3. The implantable medical device according to claim 1, wherein the coating comprises a primer layer disposed over the device body.

4. The implantable medical device according to claim 1, wherein the coating comprises a reservoir layer disposed over the device body.

5. The implantable medical device according to claim 4, wherein the reservoir layer comprises one or more bioactive agents.

6. The implantable medical device according to claim 1, wherein the coating comprises a top-coat layer disposed over a reservoir layer.

7. The implantable medical device according to claim 6, wherein the reservoir layer comprises a stereocomplex of poly(D-lactic acid) and poly(L-lactic acid).

8. A method for increasing the stability of an implantable medical device coating comprising:

providing a device body; and

disposing a coating over the device body;

wherein the coating comprises a reservoir layer and further comprises a primer layer or a topcoat,

wherein the primer layer or the topcoat comprises a stereocomplex of poly(D-lactic acid) and poly(L-lactic acid).

9. The method according to claim 8, wherein the device body comprises a stent.

10. The method according to claim 8, wherein the coating comprises a primer layer disposed over the device body.

11. The method according to claim 8, wherein the coating comprises a reservoir layer disposed over the device body.

12. The method according to claim 11, wherein the coating comprises a top-coat layer disposed over a reservoir layer.

13. The method according to claim 12, wherein the reservoir layer comprises a stereocomplex of poly(D-lactic acid) and poly(L-lactic acid).