Electrochemical biosensor measuring system

• US 8,377,272 B2
• Filed: 02/26/2008
• Issued: 02/19/2013
• Est. Priority Date: 03/02/2007
• Status: Active Grant

• Current Assignee: i-SENS, Inc.
• Original Assignee: i-SENS, Inc.
• Inventors: Kim, Keun Ki, Kim, Moon Hwan, Yoo, Jae Hyun, Cui, Gang, Nam, Hakhyun, Cha, Geun Sig
• Primary Examiner(s): Hendricks, Keith
• Assistant Examiner(s): LEONG, SUSAN DANG
• Application Number:
  US12/529,008
• Publication Number:
  US 20100032321A1
• Time in Patent Office: 1,820 Days
• Field of Search: 204/400, 20440301-40305, 2044031-40313, 204/403.14, 205/777.5, 205/778, 205/792, 600345-348, 435 4- 4052, 422/68.1, 422 8201- 8211, 422/91, 422/98, 436 62- 71, 436500-548, 235/462.01, 23546204-46205, 235/464.41
• US Class Current: 204/403.14
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: G01N 2035/00851 process control parameters
• CPC Class Codes: G01N 33/48771 Coding of information, e.g. calibration data, lot number

Abstract

Disclosed is an electrochemical biosensor measuring device which can be used together with an electrochemical biosensor. The biosensor measuring device comprises an electrical connection portion which is electrically connected with the electrodes of the biosensor upon the insertion of the biosensor there into, and a connector having a structure in which at least one light absorption or reflection path sequentially comprising a light emitter-production lot information identification portion-detector unit is provided to identify the production lot information recorded in the biosensor. The electrochemical biosensor measuring device can automatically identify the production lot information of the biosensor, encoded in the form of a hue or hole marks, upon the insertion of the electrochemical biosensor into the measuring device, thereby obviating the need to manually input the production lot information of the biosensor. Thus, inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.

Claims

1. An electrochemical biosensor measuring device, which measures an electrochemical biosensor composed of plurality of electrodes including at least a working electrode and an auxiliary electrode prepared on at least one or two insulating plates;

a capillary sample cell for introducing a sample into the electrodes;

a reaction reagent layer, formed on the working electrode, containing a redox enzyme and an electron transfer mediator;

an electrical connection portion for connecting the working electrode and the auxiliary electrode; and

a production lot information identification portion configured such that production lot information is recorded on at least one insulating plate, and does not interrupt a connection between the electrodes,

wherein the biosensor measuring device comprises a light emitter, a detector and a connector having a structure in which at least one light absorption or reflection path sequentially through a light emitter-production lot information identification portion-detector is provided to identify the production lot information recorded in the biosensor, and

wherein the connector is provided with a transmission window in one side thereof so that the light beams absorbed or reflected via the light emitter-production lot information identification portion-detector pass through the connector;

wherein the connector further includes a sliding door structure that covers a portion of the transmission window, wherein the sliding door structure provides a path through which the light beam can reach the production lot information identification portion.

2. The electrochemical biosensor measuring device according to claim 1, wherein the plurality of electrodes further include a sample fluidity determining electrode.

3. The electrochemical biosensor measuring device according to claim 1, wherein the production lot information identification portion includes at least one mark selected from a group consisting of a hue mark, a hole mark and a light-transmitting film-covered hole mark.

4. The electrochemical biosensor measuring device according to claim 3, wherein the production lot information identification portion includes one or more hue mark(s) displaying the information about differences between production lots by differences in the color, brightness, or chroma of one or more color image(s).

5. The electrochemical biosensor measuring device according to claim 3, wherein the production lot information identification portion includes one or more hole mark(s) displaying the information about differences between production lots by differences in the combination of one or more hole mark(s), each hole mark being an open or closed hole.

6. The electrochemical biosensor measuring device according to claim 3, wherein the production lot information identification portion includes one or more light-transmitting film covered hole mark(s) displaying the information about differences between production lots by differences in the degree of transmission of light through the light-transmitting film of the one or more light-transmitting film covered hole mark(s).

7. The electrochemical biosensor measuring device according to claim 4, wherein the number of the hue marks ranges from 1 to 10.

8. The electrochemical biosensor measuring device according to claim 1, wherein the light emitter is composed of three-component photodiodes that emit red, green and blue colors or four-components photodiodes that emit white, red, green and blue colors.

9. The electrochemical biosensor measuring device according to claim 1, wherein the light emitter is an infrared light source.

10. The electrochemical biosensor measuring device according to claim 1, wherein the production lot information identification portion detector is an optical identification device which identifies the production lot information by discerning differences in the color, brightness or chroma of the hue marks, hole marks or light-transmitting film-covered hole marks of the production lot information identification portion.

11. The electrochemical biosensor measuring device according to claim 4, wherein the production lot information identification portion detector is an image signal identification device which identifies the production lot information by discerning differences in the image signal of the hue mark of the production lot information identification portion.

12. The electrochemical biosensor measuring device according to claim 1, wherein the light emitter and the detector are constructed in a separate or integrated structure.

13. The electrochemical biosensor measuring device according to claim 1, wherein the connector has a body made of a transparent material.

14. The electrochemical biosensor measuring device according to claim 1, wherein the sliding door structure is connected to a device that can passively or automatically remove the biosensor.

15. The electrochemical biosensor measuring device according to claim 1, wherein the connector includes a body made of a transparent material and an electrical connection portion;

and the light emitter, the detector and the electrical connection portion are present in an integrated structure within the body.

16. A measuring method using a biosensor measuring device, comprising:

inserting the electrochemical biosensor as recited in claim 1 into the connector port of the measuring device according to claim 1 to activate its power (step 1);

identifying the production lot information of the biosensor inserted at Step 1 (step 2);

activating the measurement and operation processes of the biosensor measuring device in conformity with the production lot information identified at Step 2 (step 3); and

introducing a liquid sample to the sample inlet of the biosensor to result in quantitative electrochemical information about the sample, quantifying a specific component of the liquid sample, and displaying quantification results (step 4).

17. The measuring method according to claim 16, wherein the identifying step is carried out by detecting at least one mark selected from a group consisting of a hue mark, a hole mark and a light-transmitting film-covered hole mark.

18. The measuring method according to claim 17, wherein the hue mark displays information about differences between production lots by differences in the color, brightness, or chroma of a plurality of color images.

19. The measuring method according to claim 17, wherein the hole mark displays information about differences between production lots by differences in the combination of a plurality of holes which are independently open or closed.

20. The measuring method according to claim 17, wherein the light-transmitting-covered hole mark displays information about differences between production lots by differences in the degree of transmission of light through a plurality of light-transmitting films covering corresponding open holes.

21. The measuring method according to claim 18, wherein the number of the hue marks ranges from 1 to 10.

22. The measuring method according to claim 16, wherein the identifying the production lot information step is carried out by applying light from three-component photodiodes that emit red, green and blue colors or four-components photodiodes that emit white, red, green and blue colors to a hue mark, a hole mark or a light-transmitting film-covered hole mark of a production lot information identification portion, and detecting a variation or difference in the wavelength, color, brightness or chroma of the light according to reflection from or transmission through the mark using an optical identification device.

23. The measuring method according to claim 16, wherein the identifying the production lot information step is carried out by applying light from one or more infrared light sources capable of emitting infrared light to a hue mark, a hole mark or a light-transmitting film-covered hole mark of a production lot information identification portion, and detecting a variation or difference in the wavelength, color, brightness or chroma of the light according to the reflection from or the transmission through the mark using one or more optical identification devices.

24. The measuring method according to claim 16, wherein the identifying the production lot information step is carried out by detecting an image signal from a hue mark of a production lot information identification portion with an image signal identification device and analyzing the information encoded by the image signal.

25. The electrochemical biosensor measuring device according to claim 5, wherein the number of the hole marks ranges from 1 to 10.

26. The electrochemical biosensor measuring device according to claim 6, wherein the number of the hole marks ranges from 1 to 10.

27. The measuring method according to claim 19, wherein the number of the hole marks ranges from 1 to 10.

28. The measuring method according to claim 20, wherein the number of the hole marks ranges from 1 to 10.