Adhesive tissue repair patch
First Claim
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1. A mesh for use in the repair of herniated tissue comprising a mesh and a coating composition including:
- (a) a naturally occurring hydrophilic polymer selected from proteins, polysaccharides, and glycosaminoglycans, wherein the naturally occurring hydrophilic polymer is not methylated collagen;
(b) a first synthetic polymer having m nucleophilic groups, wherein m≧
2;
(c) a second synthetic polymer having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧
2; and
wherein each of the first synthetic polymer and the second synthetic polymer is poly (alkylene oxide) and crosslinking of the coating composition results in a biocompatible, crosslinked matrix.
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Abstract
A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Kits for use in carrying out the method of the invention are also provided, as are pretreated surgically acceptable patches that have been coated with the aforementioned adhesive composition.
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Citations
11 Claims
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1. A mesh for use in the repair of herniated tissue comprising a mesh and a coating composition including:
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(a) a naturally occurring hydrophilic polymer selected from proteins, polysaccharides, and glycosaminoglycans, wherein the naturally occurring hydrophilic polymer is not methylated collagen; (b) a first synthetic polymer having m nucleophilic groups, wherein m≧
2;(c) a second synthetic polymer having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧
2; andwherein each of the first synthetic polymer and the second synthetic polymer is poly (alkylene oxide) and crosslinking of the coating composition results in a biocompatible, crosslinked matrix. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification