Adhesive tissue repair patch

• US 8,377,466 B2
• Filed: 10/22/2004
• Issued: 02/19/2013
• Est. Priority Date: 12/18/1995
• Status: Expired due to Term

• Current Assignee: Angiodevice International GmbH (Angiotech Pharmaceuticals (US), Inc.)
• Original Assignee: Angiotech Pharmaceuticals Incorporated
• Inventors: Sehl, Louis C., Trollsas, Olof Mikael, Wallace, Donald G., Toman, David, DeLustro, Frank A., Schroeder, Jacqueline A., Chu, George H.
• Primary Examiner(s): DICKINSON, PAUL W
• Application Number:
  US10/971,684
• Publication Number:
  US 20050054771A1
• Time in Patent Office: 3,042 Days
• Field of Search: None
• US Class Current: 424/443
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 24/08 Polysaccharides A61L24/043 takes precedence
• CPC Class Codes: A61L 24/102 Collagen
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: C08B 37/0075 Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
• CPC Class Codes: C08F 283/00 Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
• CPC Class Codes: C08F 283/04 on to polycarbonamides, polyesteramides or polyimides C08F283/004 takes precedence
• CPC Class Codes: C08F 283/06 on to polyethers, polyoxymethylenes or polyacetals C08F283/004 takes precedence
• CPC Class Codes: C08G 65/329 with organic compounds
• CPC Class Codes: C08G 75/045 from mercapto compounds and unsaturated compounds
• CPC Class Codes: C08G 75/26 Polythioesters
• CPC Class Codes: C08H 1/00 Macromolecular products derived from proteins food proteins A23; glue, gelatine C09H
• CPC Class Codes: C08H 1/06 derived from horn, hoofs, hair, skin or leather
• CPC Class Codes: C08L 2666/26 Natural polymers, natural resins or derivatives thereof according to C08L1/00 - C08L5/00, C08L89/00, C08L93/00, C08L97/00 or C08L99/00
• CPC Class Codes: C08L 5/16 Cyclodextrin; Derivatives thereof
• CPC Class Codes: C08L 51/003 grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds C08L51/04, C08L51/06 take precedence
• CPC Class Codes: C08L 53/00 : Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 67/06 : Unsaturated polyesters
• CPC Class Codes: C08L 71/00 : Compositions of polyethers obtained by reactions forming an ether link in the main chain of polyacetals C08L59/00; of epoxy resins C08L63/00; of polythioether-ethers C08L81/02; of polyether-sulfones C08L81/06; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 71/02 : Polyalkylene oxides
• CPC Class Codes: C08L 81/02 : Polythioethers; Polythioether-ethers
• CPC Class Codes: C08L 89/06 : derived from leather or skin , e.g. gelatin
• CPC Class Codes: C08L 91/06 : Waxes
• CPC Class Codes: C09D 167/02 : Polyesters derived from dicarboxylic acids and dihydroxy compounds C09D167/06 takes precedence
• CPC Class Codes: C09J 151/003 : grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds C09J151/04, C09J151/06 take precedence
• CPC Class Codes: C09J 153/00 : Adhesives based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers
• CPC Class Codes: C09J 189/06 : derived from leather or skin

Abstract

A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Kits for use in carrying out the method of the invention are also provided, as are pretreated surgically acceptable patches that have been coated with the aforementioned adhesive composition.

Claims

1. A mesh for use in the repair of herniated tissue comprising a mesh and a coating composition including:

(a) a naturally occurring hydrophilic polymer selected from proteins, polysaccharides, and glycosaminoglycans, wherein the naturally occurring hydrophilic polymer is not methylated collagen;

(b) a first synthetic polymer having m nucleophilic groups, wherein m≧

2;

(c) a second synthetic polymer having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧

2; and

wherein each of the first synthetic polymer and the second synthetic polymer is poly (alkylene oxide) and crosslinking of the coating composition results in a biocompatible, crosslinked matrix.

2. The mesh of claim 1, wherein the first synthetic polymer and the second synthetic polymer are hydrophilic.

3. The mesh of claim 1, wherein m+n is 5 or more.

4. The mesh of claim 1, wherein each of the first synthetic polymer and the second synthetic polymer is nonimmunogenic.

5. The mesh of claim 1, wherein the naturally occurring hydrophilic polymer is selected from nonfibrillar collagen, succinylated collagen, fibrillar collagen, denatured collagen and combinations thereof.

6. The mesh of claim 5, wherein the nonfibrillar collagen is selected from type IV collagen, type VI collagen, and type VII collagen.

7. The mesh of claim 2, wherein the first synthetic polymer and the second synthetic polymer are polyalkylene oxides.

8. The mesh of claim 7, wherein the first synthetic polymer and the second synthetic polymer are polyethylene glycol.

9. The mesh of claim 1, wherein the nucleophilic groups of the first synthetic polymer can be the same or different and are —

NH₂, —

SH, —

OH, —

PH₂, or —

CO—

NH—

NH₂.

10. The mesh of claim 1, wherein the coating composition further comprises a biologically active agent.

11. The mesh of claim 1, wherein the electrophilic groups are a succinimidyl ester group, a succinimidyl carbonate group, and a maleimidyl group, —

COOH, —

CHO, —

N═

C═

O or —

SO₂CH—

CH₂.