Fluorescence quenching azo dyes, their methods of preparation and use
First Claim
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1. A method for detecting hybridization of nucleic acid polymers comprising:
- a) incubating a first nucleic acid polymer complimentary to a second nucleic acid polymer having, attached thereto, a quencher compound of Formula 1;
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Abstract
Disclosed is a group of azo quencher compositions useful as fluorescence quenchers having the general structure of formula 1, methods of making or using the compositions, and kits comprising the composition.
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6 Claims
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1. A method for detecting hybridization of nucleic acid polymers comprising:
a) incubating a first nucleic acid polymer complimentary to a second nucleic acid polymer having, attached thereto, a quencher compound of Formula 1; - View Dependent Claims (2, 3, 4, 5)
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6. A method for synthesizing an oligonucleotide having attached thereto a fluorescent quencher of Formula 1:
Specification