Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
First Claim
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1. A method of treating a disorder or a disease associated with neutral endopeptidase EC. 3.4. 24.11. activity in a subject in need thereof, comprising:
- administering to the subject a therapeutically effective amount of a compound formula (I′
);
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Abstract
The present invention provides a compound of formula I;
or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R6, A1, A2, X1, s and m are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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12 Claims
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1. A method of treating a disorder or a disease associated with neutral endopeptidase EC. 3.4. 24.11. activity in a subject in need thereof, comprising:
administering to the subject a therapeutically effective amount of a compound formula (I′
);- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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