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System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics

  • US 8,380,268 B2
  • Filed: 06/24/2005
  • Issued: 02/19/2013
  • Est. Priority Date: 01/19/2001
  • Status: Active Grant
First Claim
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1. A method of measuring spectral data to detect cancerous tissue comprising:

  • inserting a fiber optic probe within an endoscope channel, the endoscope being inserted within a body cavity or lumen, the fiber optic probe having a central light delivery optical fiber and a plurality of light collection optical fibers that surround the central light delivery optical fiber, the probe collecting fluorescent light and reflected light from the tissue at a plurality of wavelengths;

    illuminating tissue with light from a broadband light source optically coupled to the central light delivery optical fiber and a laser light source optically coupled to the central delivery optical fiber such that a selected region of tissue is illuminated;

    detecting the collected fluorescent light and reflected light with a detector that is optically coupled to proximal ends of the collection optical fibers;

    processing detected fluorescence light and detected reflected light with a data processor to form an intrinsic fluorescence spectrum and a diffuse reflectance spectrum; and

    determining a characteristic of the tissue using the data processor that processes the intrinsic fluorescence spectrum and the diffuse reflectance spectrum, in combination, to detect cancerous tissue.

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