Biosensor membranes composed of polymers containing heterocyclic nitrogens

• US 8,380,274 B2
• Filed: 07/16/2008
• Issued: 02/19/2013
• Est. Priority Date: 05/15/2001
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Mao, Fei, Cho, Hyun
• Primary Examiner(s): Noguerola, Alex
• Application Number:
  US12/174,121
• Publication Number:
  US 20080277277A1
• Time in Patent Office: 1,679 Days
• Field of Search: 20440301-40315, 205/777.5, 205/782, 205/792, 600345-348
• US Class Current: 600/347
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive
• CPC Class Codes: C12Q 1/002 Electrode membranes
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.

Claims

1. An electrochemical analyte sensor configured for implantation in vivo for measuring an analyte concentration in a host, the sensor comprising:

at least one electrode; and

a membrane system located over an electroactive surface of the electrode, wherein the membrane system comprises a flux-limiting domain comprising at least one hydrophilic component, wherein the flux-limiting domain does not substantially affect accuracy of an in vivo analyte concentration measurement, the flux limiting domain comprising a polymer having the formula;

2. The electrochemical analyte sensor of claim 1, wherein the flux-limiting domain further comprises at least one hydrophobic substituent.

3. The electrochemical analyte sensor of claim 1, wherein the analyte is glucose and wherein the sensor possesses a glucose sensitivity of up to 30 mM.

4. The electrochemical analyte sensor of claim 1, further comprising sensor electronics operably connected to the electrochemical analyte sensor and configured to provide a signal representative of an analyte concentration in the host, wherein the analyte is glucose.

5. The electrochemical analyte sensor of claim 1, wherein an average flux-limiting domain comprises a polymer having a molecular weight of from about 50,000 to about 200,000.

6. The electrochemical analyte sensor of claim 1, wherein the polymer further comprises a crosslinker.

7. The electrochemical analyte sensor of claim 6, wherein the crosslinker comprises an alkylating group selected from the group consisting of poly(ethylene glycol), poly(propylene glycol), epoxide (glycidyl group), aziridine, alkyl halide and sulfonate esters.

8. The electrochemical analyte sensor of claim 7, wherein the crosslinker comprises poly(ethylene glycol)diglycidyl ether.