System and method for predicting successful defibrillation for ventricular fibrillation cardiac arrest
First Claim
1. A computer-assisted method for quantitative characterization and treatment of ventricular fibrillation, comprising:
- acquiring a time series of a ventricular fibrillation (VF) signal using a probe from a patient;
subtracting a mean of the time series of the VF signal from the time series of the VF signal;
calculating a cumulative VF signal by a computer system after the mean is subtracted from the time series of the VF signal;
segmenting the cumulative VF signal by a plurality of sampling boxes by the computer system;
calculating a trend in the cumulative VF signal in each of the plurality of sampling boxes;
subtracting the trend from the cumulative VF signal in each of the plurality of sampling boxes to produce a detrended cumulative VF signal;
calculating a root-mean-square of the detrended cumulative VF signal as a function of the sampling box size by the computer system;
identifying a first region and a second region in the detrended cumulative VF signal separated by a crossover point, wherein the detrended cumulative VF signal in the first region and the second region have different exponents as a function of the sampling box size, wherein the second region has larger sampling box sizes than the first region;
extracting, by the computer system, an exponent of the root-mean-square of the detrended cumulative VF signal in the second region as a function of the sampling box size;
applying electrical defibrillation to the patient if the exponent is below a predetermined value; and
applying cardiopulmonary resuscitation (CPR) to the patient if the exponent is above a predetermined value.
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Abstract
A computer-assisted method for quantitative characterization and treatment of ventricular fibrillation includes acquiring a time series of a ventricular fibrillation (VF) signal using a probe from a patient experiencing VF, subtracting the mean from the time series of the VF signal, calculating a cumulative VF signal after the mean is subtracted from the time series of the VF signal, segmenting the cumulative VF signal by a plurality of sampling boxes, calculating the root-mean-square of the cumulative VF signal as a function of the sampling box size , extracting an exponent of the root-mean-square of the cumulative VF signal as a function of the sampling box size, applying electrical defibrillation to the patient if the exponent is below a predetermined value, and applying cardiopulmonary resuscitation (CPR) to the patient if the exponent is above a predetermined value.
31 Citations
15 Claims
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1. A computer-assisted method for quantitative characterization and treatment of ventricular fibrillation, comprising:
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acquiring a time series of a ventricular fibrillation (VF) signal using a probe from a patient; subtracting a mean of the time series of the VF signal from the time series of the VF signal; calculating a cumulative VF signal by a computer system after the mean is subtracted from the time series of the VF signal; segmenting the cumulative VF signal by a plurality of sampling boxes by the computer system; calculating a trend in the cumulative VF signal in each of the plurality of sampling boxes; subtracting the trend from the cumulative VF signal in each of the plurality of sampling boxes to produce a detrended cumulative VF signal; calculating a root-mean-square of the detrended cumulative VF signal as a function of the sampling box size by the computer system; identifying a first region and a second region in the detrended cumulative VF signal separated by a crossover point, wherein the detrended cumulative VF signal in the first region and the second region have different exponents as a function of the sampling box size, wherein the second region has larger sampling box sizes than the first region; extracting, by the computer system, an exponent of the root-mean-square of the detrended cumulative VF signal in the second region as a function of the sampling box size; applying electrical defibrillation to the patient if the exponent is below a predetermined value; and applying cardiopulmonary resuscitation (CPR) to the patient if the exponent is above a predetermined value. - View Dependent Claims (2, 3, 4, 5)
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6. A computer-assisted method for quantitative characterization and treatment of ventricular fibrillation, comprising:
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applying cardiopulmonary resuscitation (CPR) to a patient; acquiring a time series of a ventricular fibrillation (VF) signal using a probe from the patient during CPR; subtracting a mean of the time series of the VF signal from the time series of the VF signal; calculating a cumulative VF signal by a computer system after the mean is subtracted from the time series of the VF signal; segmenting the cumulative VF signal by a plurality of sampling boxes by the computer system; calculating a trend in the cumulative VF signal in each of the plurality of sampling Boxes; subtracting the trend from the cumulative VF signal in each of the plurality of sampling boxes to produce a detrended cumulative VF signal; calculating a root-mean-square of the detrended cumulative VF signal as a function of the sampling box size by the computer system; identifying a first region and a second region separated by a crossover point in the detrended cumulative VF signal, wherein the second region has larger sampling box sizes than the first region; extracting, by the computer system, an exponent of the root-mean-square of the detrended cumulative VF signal as a function of the sampling box size in the second region; and applying electrical defibrillation to the patient if the exponent decreases in response to the CPR. - View Dependent Claims (7, 8, 9, 10)
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11. A system for quantitative characterization and treatment of ventricular fibrillation, comprising:
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a probe configured to acquire a time series of a ventricular fibrillation (VF) signal using a probe from a patient; and a computer processor in communication with the probe, wherein the computer processor is configured to subtract a mean of the time series of the VF signal from the time series of the VF signal, to calculate a cumulative VF signal after the mean is subtracted from the time series of the VF signal, to segment the cumulative VF signal by a plurality of sampling boxes, to calculate a trend in the cumulative VF signal in each of the plurality of sampling boxes and to subtract the trend from the cumulative VF signal in each of the plurality of sampling boxes to produce a detrended cumulative VF signal, to calculate a root-mean-square of the detrended cumulative VF signal as a function of the sampling box size, identify a first region and a second region in the detrended cumulative VF signal, and to extract an exponent of the root-mean-square of the cumulative VF signal in the second region as a function of the sampling box size, wherein the second region has larger sampling box sizes than the first region, wherein the computer processor is configured to recommend electrical defibrillation to the patient if the exponent is below a predetermined value, wherein the computer processor is configured to recommend application of cardiopulmonary resuscitation (CPR) to the patient if the exponent is above a predetermined value. - View Dependent Claims (12, 13, 14, 15)
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Specification