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Methods for loading a drug eluting medical device

  • US 8,381,774 B2
  • Filed: 09/17/2010
  • Issued: 02/26/2013
  • Est. Priority Date: 09/20/2009
  • Status: Expired due to Fees
First Claim
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1. A method of loading a therapeutic substance within a lumenal space of a hollow wire that forms a hollow stent for drug delivery comprising the steps of:

  • preparing a suspension of the therapeutic substance and a dispersion medium;

    placing the suspension within a high-pressure packing unit;

    fluidly connecting a first end of the hollow wire to the packing unit such that the lumenal space of the hollow wire is in fluid communication with the suspension;

    attaching an end fitting having a frit to a second end of the hollow wire, wherein a pore size of the frit is selected to prevent particles of the therapeutic substance from passing there through while allowing the dispersion medium to pass there through; and

    pressurizing the packing unit to a packing pressure that forces the suspension into the lumenal space of the hollow wire, whereby the therapeutic substance packs within the lumenal space of the hollow wire as the therapeutic substance is separated from the dispersion medium that is forced through the frit at the second end of the hollow wire.

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