Lift and support assemblies and methods for collapsible bag containers of vessels and bioreactors

• US 8,381,780 B2
• Filed: 05/20/2009
• Issued: 02/26/2013
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Global Life Sciences Solutions USA LLC (Danaher Corporation)
• Original Assignee: Xcellerex, Inc. (General Electric Company)
• Inventors: Fisher, Michael, Galliher, Parrish M.
• Primary Examiner(s): Lowe, Scott
• Application Number:
  US12/469,469
• Publication Number:
  US 20090290962A1
• Time in Patent Office: 1,378 Days
• Field of Search: 414/287, 414/808, 141/114, 141/314, 294/68.3
• US Class Current: 141/314
• CPC Class Codes: B01F 2101/44 Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
• CPC Class Codes: C12M 23/14 Bags
• CPC Class Codes: C12M 23/48 Holding appliances; Racks; Supports holding devices for laboratory apparatus B01L9/00
• CPC Class Codes: C12M 23/50 Means for positioning or orientating the apparatus C12M41/08 takes precedence

Abstract

Disclosed are a lift assembly and methods that may be used to raise a component of a system, a component such as a collapsible bag to be used as a reactor for performing chemical or biological reactions, and/or to position the collapsible bag for use. Use of the lift assembly may allow for the automated assembly of the systems described herein. In some cases, trauma to the system components is minimized.

Claims

1. A lift assembly for installing, lifting, or supporting a collapsible bag within a vessel configured to contain a volume of fluid, comprising:

an assembly support structure adapted to be attached at least to opposite sides of a top portion of the vessel wherein the vessel comprises an entry port positioned at a bottom portion of the vessel, the entry port adapted to allow entry of the collapsible bag into the vessel;

a lifting component mounted on the assembly support structure and vertically movable relative to the assembly support structure, and wherein the lifting component is extendable to at least the level of the entry port, the lifting component configured and arranged to be attached to the collapsible bag to be installed in the vessel, or supported or lifted within the vessel, and to lift at least an upper portion of the collapsible bag to convert the collapsible bag from a collapsed to an uncollapsed configuration and to support the collapsible bag in the uncollapsed configuration; and

a motive device for vertically moving the lifting component relative to the assembly support structure, wherein the motive device further comprises

a motor mounted above the vessel supported at least in part by the assembly support structure and mechanically linked to the lifting component

a controller to control the raising, lowering, and/or stopping of the lifting component via the motor, and

a strain interlock to prevent tearing of the collapsible bag that may be caught or obstructed during installation or removal.

2. A lift assembly as in claim 1, wherein the lifting component comprises a lifting bar.

3. A lift assembly as in claim 2, wherein the lifting bar comprises a hook configured to engage a portion of the top of the collapsible bag.

4. A lift assembly as in claim 1, wherein the lifting component comprises a plurality of lifting bars.

5. A lift assembly as in claim 1, further comprising a cable or chain including a first end connected directly or indirectly to the lifting component and a second end connected directly or indirectly to the motive device.

6. A lift assembly as in claim 1, wherein the motive device comprises a pulley system.

7. A lift assembly as in claim 1, wherein the assembly support structure comprises one or more support bars, each bar attached at least to opposite sides of a top portion of the vessel.

8. A method for installing and/or lifting a collapsible bag within a vessel with a lift assembly according to claim 1, comprising:

extending the lifting component from a top portion to a bottom portion of the vessel;

directing the lifting component towards the entry port positioned at the bottom portion of the vessel such that at least a part of the lifting component is positioned at or near the entry port;

attaching the collapsible bag to at least a portion of the lifting component;

activating a motor associated with the lifting assembly via a controller to direct the lifting component and the collapsible bag towards the top portion of the vessel;

monitoring strain during lifting and

stopping the lifting component if necessary to prevent tearing of the collapsible bag that may be caught or obstructed during installation or removal.

9. A method as in claim 8, wherein extending the lifting component from the top portion to the bottom portion of the vessel comprises extending a cable or chain attached to the lifting component.

10. A method as claimed in claim 8, wherein the at least a part of the lifting component positioned at or near the entry port is directed through the entry port such that the at least a part of the lifting component is positioned exterior to the interior portion of the vessel prior to attaching the article to at least a portion of the lifting component.

11. A lift assembly as in claim 1, wherein the assembly support structure comprises a ring having a circumference substantially similar to the circumference of the vessel to which the assembly support structure is attached.

12. A lift assembly as in claim 1, wherein the assembly support structure has a form that is chosen from a dome shaped structure and a substantially planar structure.

13. A system comprising

a vessel comprising:

an entry port positioned at a bottom portion of the vessel, the entry port adapted to allow entry of a collapsible bag into the vessel;

the collapsible bag configured to contain a volume of a fluid,

a support structure surrounding and containing the collapsible bag; and

a lift assembly comprising

an assembly support structure attached at least to opposite sides of a top portion of the vessel,

a lifting component mounted on the assembly support structure and vertically movable relative to the assembly support structure, and wherein the lifting component is extendable to at least the level of the entry port and through the entry port, such that at least a part of the lifting component can be positioned exterior to the interior portion of the vessel to facilitate being attached to an article, the lifting component configured and arranged to be attached to the collapsible bag to be installed in the vessel, or supported or lifted within the vessel, and to lift at least an upper portion of the collapsible bag to convert the collapsible bag from a collapsed to an uncollapsed configuration and to support the collapsible bag in the uncollapsed configuration; and

a motive device for vertically moving the lifting component relative to the assembly support structure, wherein the motive device further comprises

a motor mounted above the vessel supported at least in part by the assembly support structure and mechanically linked to the lifting component

a controller to control the raising, lowering, and/or stopping of the lifting component via the motor, and

a strain interlock to prevent tearing of the collapsible bag that may be caught or obstructed during installation or removal.

14. A system as in claim 13, wherein the lifting component comprises at least one lifting bar.

15. A system as in claim 13, wherein the entry port is sized to allow passage of a collapsible bag having a volume of at least 10 L, and wherein the vessel comprises an entry port cover removably attached to the vessel.

16. A system as in claim 13, comprising a plurality of rods attached to an upper surface of the collapsible bag, the rods configured to be engaged by the lifting component of the lift assembly to enable the lift assembly to lift and support at least the upper surface of the collapsible bag.

17. A system as in claim 16, wherein the upper surface of the collapsible bag comprises a plurality of sleeves, and wherein each sleeve contains one of the plurality of rods.