Apparatus, system, and method for modulating consolidation of memory during sleep

• US 8,382,484 B2
• Filed: 04/04/2012
• Issued: 02/26/2013
• Est. Priority Date: 04/04/2011
• Status: Active Grant

• Current Assignee: Sheepdog Sciences, Inc.
• Original Assignee: Sheepdog Sciences, Inc.
• Inventors: Wetmore, Daniel Z., Anderson, Todd O., Barretto, Robert J., Butterwick, Alexander F. A.
• Primary Examiner(s): Utama, Robert J
• Application Number:
  US13/439,715
• Publication Number:
  US 20120251989A1
• Time in Patent Office: 328 Days
• Field of Search: 434/156, 434/157, 434/236, 434/238
• US Class Current: 434/236
• CPC Class Codes: A61M 2021/0016 by the smell sense
• CPC Class Codes: A61M 2021/0022 by the tactile sense, e.g. vibrations
• CPC Class Codes: A61M 2021/0027 by the hearing sense
• CPC Class Codes: A61M 2021/0044 by the sight sense
• CPC Class Codes: A61M 2021/0072 with application of electrical currents
• CPC Class Codes: A61M 2021/0077 with application of chemical or pharmacological stimulus
• CPC Class Codes: A61M 21/00 Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/609 Biometric patient identification means
• CPC Class Codes: A61M 2209/086 Docking stations
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/10 Electroencephalographic signals
• CPC Class Codes: A61M 2230/14 : Electro-oculogram [EOG]
• CPC Class Codes: A61M 2230/205 : partial oxygen pressure (P-O2)
• CPC Class Codes: A61M 2230/42 : Rate
• CPC Class Codes: A61M 2230/50 : Temperature
• CPC Class Codes: A61M 2230/60 : Muscle strain, i.e. measured on the user
• CPC Class Codes: A61M 2230/62 : Posture
• CPC Class Codes: A61M 2230/63 : Motion, e.g. physical activity
• CPC Class Codes: A61M 2230/65 : Impedance, e.g. conductivity, capacity
• CPC Class Codes: G09B 19/00 : Teaching not covered by other main groups of this subclass teaching or practice apparatus for gun-aiming or gun-laying F41G3/26

Abstract

Devices, systems and methods to modify memory and/or cognitive function by delivering a sensory stimulus paired with learned material at opportune physiological periods during sleep. For example, described herein are systems, methods and devices to enhance a user'"'"'s cognitive function in such areas as memorization and learning. A machine (e.g., a system or device) may be used to identify opportune periods of the sleep cycle and to deliver a stimulus during specific phases of the sleep cycle to facilitate or interrupt memory consolidation. In some variations the machine records ambient sensory inputs during awake acquisition or reinforcement/relearning and replays all or an extracted form of the ambient sensory stimuli a specified portion of the user'"'"'s sleep.

Claims

1. A system for improving memory having a training mode and a sleep consolidation mode, the system comprising:

a user interface comprising a control allowing a user to switch the device to the training mode to indicate a training session;

a sensory stimulator configured to provide a plurality of distinct sensory stimuli;

a sleep monitor configured to monitor a user'"'"'s sleep state without contacting the user'"'"'s head;

a controller comprising control logic receiving input from the user interface and configured to select a contextual sensory stimulus for a specific training session and to control the application of the contextual sensory stimulus, wherein the controller receives information on the user'"'"'s sleep state from the sleep monitor, and controls the sensory stimulator to apply the contextual sensory stimulus from the specific training session according to a training schedule when the user is experiencing slow wave sleep during a sleep consolidation mode; and

a learning database configured to be populated with training content and contextual sensory stimuli co-presented with the training content,

wherein the controller is configured to use information from the database to determine the training schedule by selecting which contextual sensory stimuli to repeat and when to repeat each sensory stimuli associated with particular training content over multiple nights of sleep.

2. The system of claim 1, wherein the sensory stimulator is configured to provide an ambient sensory stimulus recorded during the training session.

3. The system of claim 2, wherein the sensory stimulator comprises an ambient recorder for recording the ambient stimulus wherein the ambient recorder is configured to record one or more of ambient sounds, ambient odors, and ambient sensations.

4. The system of claim 1, further comprising a memory connected to the controller.

5. The system of claim 4, wherein the memory is configured to store information that indicates one or more of:

which sensory stimuli have been applied for specific training sessions, the sleep state of user, and completion of application of a sensory stimulus during a sleep consolidation mode following a specific training session.

6. The system of claim 1, wherein the sensory stimulator is configured to deliver one or more of:

olfactory stimuli, auditory stimuli and tactile stimuli.

7. The system of claim 1, further comprising housing at least partially enclosing the user interface, sensory stimulator, and controller.

8. The system of claim 1, further comprising a communications module coupled to the controller configured to allow communication with a remote site.

9. The system of claim 1, wherein the control logic comprises an application configured to be executed on a mobile device.

26. The system of claim 1, wherein the sleep monitor comprises a motion-sensing sleep monitor.

27. The system of claim 26, wherein the motion-sensing sleep monitor also detects heart-rate.

28. The system of claim 1, wherein the controller is configured to determine the training schedule for repetition of sensory stimuli associated with particular training content using user feedback.

29. The system of claim 1, wherein the controller is configured to determine the training schedule for repetition of sensory stimuli associated with particular training content using one or more training optimization algorithms.

10. A portable user-controllable device for improving memory, the device comprising:

a user interface comprising a control allowing a user to place the device into a training mode indicating a training session;

a sensory stimulator configured to present a plurality of distinct sensory stimuli;

sleep monitoring logic configured to determine using user motion and heart rate when the user is in slow wave sleep;

a controller comprising control logic configured to determine a specific sensory stimulus received by the user concurrent with a particular training session;

wherein the controller is further configured to reapply the specific sensory stimulus when the user is in slow wave sleep following the training session;

a housing at least partially enclosing the user interface, sensory stimulator, and controller; and

a learning database configured to be populated with training content and contextual sensory stimuli co-presented with the training content,

wherein the controller is configured to use information from the database to determine a training schedule by selecting which contextual sensory stimuli to repeat and when to repeat each sensory stimuli associated with particular training content over multiple nights of sleep.

11. The device of claim 10, wherein the control logic comprises a set of distinct sensory stimuli to be presented during a particular training session.

12. The device of claim 10, wherein the sensory stimulator is configured to deliver one or more of olfactory stimuli, auditory stimuli, and tactile stimuli.

13. A system for improving memory having a training mode and a sleep consolidation mode, the system comprising:

a user interface comprising a control allowing a user to switch the device to the training mode to indicate a training session;

a sensory stimulator configured to play back an ambient stimulus recorded during a training session;

a sleep monitor configured to monitor when the user is in slow wave sleep without contacting the user'"'"'s head;

a controller comprising control logic receiving input from the user interface and configured to cause the system to record the ambient stimulus during the training session, further wherein the controller receives information on the patient'"'"'s sleep state from the sleep monitor, and controls the sensory stimulator to apply the recorded ambient stimulus when the user is experiencing slow wave sleep following the specific training session; and

a learning database configured to be populated with training content and contextual sensory stimuli co-presented with the training content,

wherein the controller is configured to use training content from the database to determine a training schedule by selecting which contextual sensory stimuli to repeat and when to repeat each sensory stimuli associated with particular training content over multiple nights of sleep.

14. The system of claim 13, further comprising an ambient recorder for recording the ambient stimulus.

15. The system of claim 13, wherein the ambient recorder is configured to record one or more of ambient sounds, ambient odors, and ambient sensations.

16. The system of claim 13, wherein the sensory stimulator is configured to access one or more sources of ambient stimuli that are active during the training session.

17. The system of claim 13, wherein the sensory stimulator is configured to deliver one or more of olfactory stimuli;

auditory stimuli;

or tactile stimuli.

18. The system of claim 13, further comprising housing at least partially enclosing the user interface, sensory stimulator, and controller.

19. The system of claim 13, further comprising a communications module coupled to the controller configured to allow communication with a remote site.

20. The system of claim 13, wherein the control logic comprises an application configured to be executed on a mobile device.

21. A method of improving memory with a user-controlled device, the method comprising:

selecting, in a user-controlled device, contextual sensory stimuli that are received by the user during one or more learning periods;

populating a learning database with training content and contextual sensory stimuli co-presented with the training content during the one or more learning periods;

determining a training schedule by selecting which contextual sensory stimuli to repeat and when to repeat each contextual sensory stimuli during a plurality of slow wave sleep stages;

detecting user motion, with the user-controlled device, and determining a slow wave sleep stage in the user from the user motion without contacting the user'"'"'s head; and

delivering, from the user-controlled device, contextual sensory stimulus to the user during the slow wave sleep stage according to the training schedule.

22. The method of claim 21, further comprising delivering, from the user-controlled device, contextual sensory stimulus to the user during the one or more learning periods.

23. The method of claim 21, wherein selecting contextual sensory stimuli comprises recording ambient sensory stimuli during one or more learning periods.

24. The method of claim 21, wherein selecting the contextual sensory stimuli comprises choosing sensory stimuli from among a plurality of non-distracting sensory stimuli that have not previously been delivered by the user-controlled device during a learning period.

25. The method of claim 21, wherein selecting the contextual sensory stimuli comprises selecting one or more of:

an olfactory stimulus;

an auditory stimulus; and

a tactile stimulus.