Systems and methods of delivering a dilated slurry to a patient

• US 8,382,704 B2
• Filed: 12/20/2007
• Issued: 02/26/2013
• Est. Priority Date: 12/29/2006
• Status: Expired due to Fees

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Medrad Incorporated (Bayer AG)
• Inventors: Uber, Arthur E. III, Griffiths, David M., Reilly, David M., Hirschman, Alan D., Cowan, Kevin P., Trocki, Mark
• Primary Examiner(s): Mehta, Bhisma
• Assistant Examiner(s): WILSON, LARRY ROSS
• Application Number:
  US11/960,968
• Publication Number:
  US 20090012497A1
• Time in Patent Office: 1,895 Days
• Field of Search: 604 82- 91, 604/191, 604/231, 604/500, 604/522
• US Class Current: 604/82
• CPC Class Codes: A61M 2202/09 Body tissue
• CPC Class Codes: A61M 5/1407 Infusion of two or more substances
• CPC Class Codes: A61M 5/14216 Reciprocating piston type
• CPC Class Codes: A61M 5/14236 Screw, impeller or centrifugal type pumps
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: B01F 27/1121 pin-shaped
• CPC Class Codes: B01F 27/119 Stirrers with rigid wires or flexible rods
• CPC Class Codes: B01F 27/50 Pipe mixers, i.e. mixers wherein the materials to be mixed flow continuously through pipes, e.g. column mixers
• CPC Class Codes: B01F 27/724 with a single helix closely surrounded by a casing
• CPC Class Codes: B01F 29/81 with stationary mixing elements
• CPC Class Codes: B01F 31/441 performing a rectilinear reciprocating movement
• CPC Class Codes: B01F 31/65 the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
• CPC Class Codes: B01F 31/651 Mixing by successively aspirating a part of the mixture in a conduit, e.g. a piston, and reinjecting it through the same conduit into the receptacle
• CPC Class Codes: B01F 31/841 with a vibrating element inside the tube
• CPC Class Codes: B01F 33/452 using independent floating stirring elements
• CPC Class Codes: B01F 33/5011 portable during use, e.g. hand-held
• CPC Class Codes: B01F 33/50112 of the syringe or cartridge type

Abstract

A system for delivering a cell-slurry to a patient may include a fluid, cells that are non-dissolvable or immiscible in the fluid, thereby forming the cell-slurry, a syringe adapted to contain the cell-slurry and a supernate of the cell-slurry, the syringe defining a first end having an outlet through which the cell-slurry is delivered to the patient, a fluidizing system associated with the syringe and adapted to effect dilation of the cell-slurry with a portion of the supernate, to form a dilated cell-slurry, the dilated cell-slurry being transferred from the fluidizing system to the syringe, while maintaining at least a portion of the supernate, the cell-slurry and supernate being transferred from the fluidizing system to the syringe, a pressurizing mechanism adapted to create a pressure to cause the dilated cell-slurry contained within the syringe to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system, the pressurizing mechanism and movement of the dilated cell-slurry.

Claims

1. A system for delivering a cell-slurry to a patient, comprising:

a fluid;

cells that are non-dissolvable or immiscible in the fluid, thereby forming the cell-slurry;

a syringe adapted to contain the cell-slurry and a supernate of the cell-slurry, the syringe defining a first end having an outlet through which the cell-slurry is delivered to the patient;

a fluidizing system associated with the syringe and adapted to effect dilation of the cell-slurry with a portion of the supernate, to form a dilated cell-slurry, the dilated cell-slurry being transferred from the fluidizing system to the syringe, while maintaining a remaining portion of the supernate, the cell-slurry and supernate being transferred from the fluidizing system to the syringe;

a pressurizing mechanism adapted to create a pressure to cause the dilated cell-slurry contained within the syringe to flow for delivery to the patient; and

a control unit in communication with and adapted to control the fluidizing system, the pressurizing mechanism, and movement of the dilated cell-slurry,

wherein the pressurizing mechanism comprises at least a first plunger slidably disposed within the syringe,

and wherein the syringe further comprises an inlet near the outlet of the first end and a pump connected to said inlet, said pump and said inlet operate to deliver additional fluid as the dilated cell-slurry is delivered to the patient.

2. The system of claim 1 wherein the fluidizing system comprises a bulk motion system adapted to impart motion to the syringe or to a portion of the syringe.

3. The system of claim 1 wherein the fluidizing system comprises a stirring system and is adapted to impart motion to the cell-slurry.

4. The system of claim 3 wherein the stirring system comprises a moveable element.

5. The system of claim 4 wherein the moveable element is a plunger, the plunger being rotatable about an axis thereof.

6. The system of claim 1 wherein the control unit comprises a processing/memory unit, a user interface adapted to allow an operator to program the control unit and a communications interface in communications with one or more additional systems.

7. The system of claim 1, further comprising a sensor in communication with the control unit and associated with the syringe, the sensor adapted to determine an amount of dilation of the cell-slurry.

8. The system of claim 1 wherein the pump is a syringe.

9. The system of claim 1 wherein the control unit is further adapted to control the pump.

10. The system of claim 9 wherein an amount of the additional fluid delivered via the inlet and the pump is measured by a sensor and controlled by the control unit.