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Genetic test module with low oligonucleotide probe mass and reagent volumes

  • US 8,383,064 B2
  • Filed: 06/01/2011
  • Issued: 02/26/2013
  • Est. Priority Date: 06/17/2010
  • Status: Expired due to Fees
First Claim
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1. A test module for performing a genetic diagnostic assay, the test module comprising:

  • an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for a biological sample containing target nucleic acid sequences;

    an array of chambers containing probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, each of the chambers containing less than 270 picograms of probe;

    a flow-path extending from the receptacle to the probes; and

    ,a reagent reservoir containing a reagent for addition to the sample in the flow-path upstream of the probes, the reagent reservoir having a volume less than 1000,000,000 cubic microns;

    wherein,the reagent reservoir has an outlet with a surface tension valve for retaining the reagent in the reservoir with a reagent meniscus until contact with the biological sample removes the reagent meniscus.

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