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Hydrogel composition to enhance fluorescence

  • US 8,383,415 B2
  • Filed: 10/13/2005
  • Issued: 02/26/2013
  • Est. Priority Date: 10/13/2005
  • Status: Expired due to Fees
First Claim
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1. A composition comprising:

  • a hydrogel material comprising hydrogel particles crosslinked by enzyme-degradable crosslinkers made from a protein, polysaccharide, peptide or polypeptide and a fluorophore incorporated into the crosslinkages of the hydrogel material, wherein said composition produces an enhanced fluorescent signal when excited by an energy source capable of exciting the fluorophore, wherein the enhanced fluorescent signal generated by the composition of the hydrogel particle and a fluorophore said intensity is greater than the intensity of a fluorescent signal generated by a composition comprising the fluorophore in the absence of the hydrogel particle.

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