Method for customized dispensing of variable dose drug combination products for individualizing of therapies

• US 8,383,579 B2
• Filed: 08/03/2011
• Issued: 02/26/2013
• Est. Priority Date: 11/19/2004
• Status: Active Grant

• Current Assignee: GlaxoSmithKline LLC (GlaxoSmithKline PLC)
• Original Assignee: GlaxoSmithKline LLC (GlaxoSmithKline PLC)
• Inventors: Kirsh, Richard L., Finkelmeier, Steven D., Glinecke, Robert, Martini, Luigi
• Primary Examiner(s): HENLEY III, RAYMOND J
• Application Number:
  US13/197,486
• Publication Number:
  US 20120029030A1
• Time in Patent Office: 573 Days
• Field of Search: 514/1.1, 514/360, 514/423
• US Class Current: 514/1.1
• CPC Class Codes: A23L 33/30 Dietetic or nutritional methods, e.g. for losing weight A23L33/10 takes precedence
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/2072 characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms A61K9/0004, A61K9/0056, A61K9/0065 take precedence
• CPC Class Codes: A61K 9/209 containing drug in at least two layers or in the core and in at least one outer layer
• CPC Class Codes: A61K 9/2095 Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing mechanical aspects A61J3/00
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Generally the method involves identifying the concentration of each of two or more active therapeutics tailored to treat a particular patient'"'"'s unique metabolism and one or more diseases, communicating that information to a producer who has multiple fixed or variable concentrations of each active available, where the producer then combines the individual concentrations of each active into single units such as a tablets or pills, and distributes those indirectly or directly to the patient.

Claims

1. A method, comprising:

a) compressing each of a plurality of formulations into a corresponding solid physical form, each of said physical forms having a concentration of active agent;

b) stockpiling said solid physical forms with a group which has the capacity to combine a plurality of said solid physical forms into a single unit;

c) identifying two or more of said solid physical forms to treat a particular patient;

d) communicating said solid physical forms identified in step (c) to said group stockpiling said solid physical forms;

e) wherein said group combines said solid physical forms identified in step (c) into said single unit; and

f) distributing said single unit indirectly or directly to the patient.

3. The method of claim 1, wherein said solid physical forms identified in step (c) are combined into said single unit with an adhesive.

5. The method of claim 1, wherein said solid physical forms identified in step (c) are combined into said single unit with a weld.

7. The method of claim 1, wherein said solid physical forms identified in step (c) are combined into said single unit with a mechanical connection.

8. The method of claim 7, wherein each of said solid physical forms has a part thereon for forming said mechanical connection with an adjacent one of said solid physical forms when combined into said single unit.

2. A method, comprising:

a) compressing each of a plurality of formulations into a corresponding solid physical form, each of said physical forms having a concentration of active agent;

b) stockpiling said solid physical forms with a first group;

c) identifying two or more of said solid physical forms to treat a particular patient;

d) communicating said two or more physical solid forms identified in step (c) to said first group;

e) supplying said two or more physical solid forms identified in step (c) to a second group which combines said two or more physical solid forms identified in step (c) into a single unit; and

f) distributing said single unit indirectly or directly to the patient.

4. The method of claim 2, wherein said solid physical forms identified in step (c) are combined into said single unit with an adhesive.

6. The method of claim 2, wherein said solid physical forms identified in step (c) are combined into said single unit with a weld.

9. The method of claim 2, wherein said solid physical forms identified in step (c) are combined into said single unit with a mechanical connection.

10. The method of claim 9, wherein each of said solid physical forms has a part thereon for forming said mechanical connection with an adjacent one of said solid physical forms when combined into said single unit.