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Stable laquinimod preparations

  • US 8,383,645 B2
  • Filed: 08/07/2012
  • Issued: 02/26/2013
  • Est. Priority Date: 06/12/2006
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or a pharmaceutically acceptable salt thereof, N-methylglucamine, and a pharmaceutically acceptable carrier, wherein the amount of N-methylglucamine is such that it reduces the degradation of N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or a pharmaceutically acceptable salt thereof in the composition relative to a corresponding formulation without N-methylglucamine.

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