Nitridoosmium(VI) complexes for treatment of cancer

• US 8,383,673 B2
• Filed: 03/19/2010
• Issued: 02/26/2013
• Est. Priority Date: 03/19/2010
• Status: Active Grant

• Current Assignee: City University of Hong Kong, Versitech Limited (Government of Hong Kong Special Administrative Region)
• Original Assignee: City University of Hong Kong, Versitech Limited (Government of Hong Kong Special Administrative Region)
• Inventors: Lau, Tai Chu, Lam, Yun Wah, Man, Wai Lun, Ni, Wen Xiu, Che, Chi-Ming
• Primary Examiner(s): Kosack, Joseph
• Assistant Examiner(s): COUGHLIN, MATTHEW P
• Application Number:
  US12/727,732
• Publication Number:
  US 20110230456A1
• Time in Patent Office: 1,075 Days
• Field of Search: 514/492, 514/186, 514/184, 548/108, 548/109, 556/137
• US Class Current: 514/492
• CPC Class Codes: A61K 31/28 Compounds containing heavy metals
• CPC Class Codes: A61K 31/555 containing heavy metals, e.g. hemin, hematin, melarsoprol
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07F 15/0026 without a metal-carbon linkage

Abstract

The invention relates to nitridoosmium complexes and methods of using these compounds as treatments for cancer.

Claims

1. A method of treating a proliferative disorder comprising administering to a patient that has said disorder a therapeutically effective amount of at least one complex according to Formula I

2. A method according to claim 1, wherein said complex is selected from

3. A method of treating a proliferative disorder comprising administering to a patient that has said disorder a therapeutically effective amount of at least one complex according to Formula I

4. A method according to claim 3, wherein said complex is selected from