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Contact lens integrated with a biosensor for the detection of glucose and other components in tears

  • US 8,385,998 B2
  • Filed: 10/26/2009
  • Issued: 02/26/2013
  • Est. Priority Date: 10/24/2008
  • Status: Active Grant
First Claim
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1. A contact lens with integrated biosensor, comprising:

  • a) a contact lens having incorporated therein a biosensor for sensing bioanalytes present in tears;

    b) the biosensor including a physiologically compatible oxygen permeable substantially transparent and flexible substrate, and physiologically compatible porous nanostructures adhered on said physiologically compatible oxygen permeable and flexible substrate, a physiologically compatible fluorescent assay containing at least one physiologically compatible fluorescent dye encapsulated in said physiologically compatible porous nanostructures,said physiologically compatible fluorescent dye being selected to react or bind with a selected bioanalyte present in tears such that reacting or binding of the bioanalyte with the physiologically compatible fluorescent dye is responsively accompanied by a detectable change in optical properties of the physiologically compatible fluorescent dye indicative of the presence of the bioanalyte in tears when the contact lenses with integrated biosensor is on a person'"'"'s eye and said physiologically compatible porous nanostructures having a porosity selected for collecting the tears; and

    c) said biosensor being located in said contact lens at a position off centre in the contact lens such as to not directly obstruct the vision of the person wearing the contact lens.

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