Contact lens integrated with a biosensor for the detection of glucose and other components in tears
First Claim
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1. A contact lens with integrated biosensor, comprising:
- a) a contact lens having incorporated therein a biosensor for sensing bioanalytes present in tears;
b) the biosensor including a physiologically compatible oxygen permeable substantially transparent and flexible substrate, and physiologically compatible porous nanostructures adhered on said physiologically compatible oxygen permeable and flexible substrate, a physiologically compatible fluorescent assay containing at least one physiologically compatible fluorescent dye encapsulated in said physiologically compatible porous nanostructures,said physiologically compatible fluorescent dye being selected to react or bind with a selected bioanalyte present in tears such that reacting or binding of the bioanalyte with the physiologically compatible fluorescent dye is responsively accompanied by a detectable change in optical properties of the physiologically compatible fluorescent dye indicative of the presence of the bioanalyte in tears when the contact lenses with integrated biosensor is on a person'"'"'s eye and said physiologically compatible porous nanostructures having a porosity selected for collecting the tears; and
c) said biosensor being located in said contact lens at a position off centre in the contact lens such as to not directly obstruct the vision of the person wearing the contact lens.
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Abstract
The present invention provides contact lens with integrated biosensor for the continuous, non-invasive monitoring of physiological glucose by employing biocompatible nanostructure-laden lens materials. These contact lenses can be worn by diabetics who can colorimetrically see changes in their contact lens color or other fluorescence-based properties, giving an indication of tear and blood glucose levels. This invention for the glucose biosensor based on the new disposal contact lens provides a safe, convenient and non-expensive glucose sensing device. The sensing device disclosed herein provides an efficient and noninvasive solution for monitoring blood glucose.
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Citations
23 Claims
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1. A contact lens with integrated biosensor, comprising:
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a) a contact lens having incorporated therein a biosensor for sensing bioanalytes present in tears; b) the biosensor including a physiologically compatible oxygen permeable substantially transparent and flexible substrate, and physiologically compatible porous nanostructures adhered on said physiologically compatible oxygen permeable and flexible substrate, a physiologically compatible fluorescent assay containing at least one physiologically compatible fluorescent dye encapsulated in said physiologically compatible porous nanostructures, said physiologically compatible fluorescent dye being selected to react or bind with a selected bioanalyte present in tears such that reacting or binding of the bioanalyte with the physiologically compatible fluorescent dye is responsively accompanied by a detectable change in optical properties of the physiologically compatible fluorescent dye indicative of the presence of the bioanalyte in tears when the contact lenses with integrated biosensor is on a person'"'"'s eye and said physiologically compatible porous nanostructures having a porosity selected for collecting the tears; and c) said biosensor being located in said contact lens at a position off centre in the contact lens such as to not directly obstruct the vision of the person wearing the contact lens. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification