Method for electrical stimulation of cutaneous sensory receptors

• US 8,386,005 B2
• Filed: 05/07/2010
• Issued: 02/26/2013
• Est. Priority Date: 10/19/2004
• Status: Active Grant

• Current Assignee: Meagan Medical, Inc.
• Original Assignee: Meagan Medical, Inc.
• Inventors: Schouenborg, Jens Olaf Roe
• Primary Examiner(s): Lavert, Nicole F
• Application Number:
  US12/776,160
• Publication Number:
  US 20100280573A1
• Time in Patent Office: 1,026 Days
• Field of Search: 600/372, 600/393, 607/115
• US Class Current: 600/372
• CPC Class Codes: A61H 39/002 Using electric currents electrotherapy A61N1/32
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0468 Specially adapted for promoting wound healing
• CPC Class Codes: A61N 1/0476 Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
• CPC Class Codes: A61N 1/0502 Skin piercing electrodes
• CPC Class Codes: A61N 1/36021 for treatment of pain

Abstract

A method of stimulating sensory nerves is disclosed that comprises the steps of providing an electrode plate with a pattern of needle-like (NL) electrodes and conductive plate (CP) electrodes disposed on a front face of the plate element, the NL electrodes being configured to apply electrical stimulation to cutaneous Aδ/C fibers, and the CP electrodes being configured to apply electrical stimulation to cutaneous Aβ fibers; mounting the electrode plate on a patient'"'"'s skin with the front face in an abutting relationship with the patient'"'"'s skin, the abutting relationship causing the NL electrodes to penetrate the epidermis of the patient'"'"'s skin; and applying electrical stimulation to the patient'"'"'s skin via the pattern of NL electrodes and CP electrodes, the electrical stimulation being applied so that Aβ fiber input from the CP electrodes overlaps in time at the patient'"'"'s spinal cord and/or brain stem with Aδ/C fiber input from the NL electrodes.

Claims

1. A method of stimulating sensory nerves comprising:

providing an electrode plate with a pattern of needle-like (NL) electrodes and conductive plate (CP) electrodes disposed on a front face of the plate element, the NL electrodes being configured to apply electrical stimulation to cutaneous Aδ

/C fibers, and the CP electrodes being configured to apply electrical stimulation to cutaneous Aβ

fibers;

mounting the electrode plate on a patient'"'"'s skin with the front face in an abutting relationship with the patient'"'"'s skin, the abutting relationship causing the NL electrodes to penetrate the epidermis of the patient'"'"'s skin; and

applying electrical stimulation to the patient'"'"'s skin via the pattern of NL electrodes and CP electrodes, the electrical stimulation being applied so that Aβ

fiber input from the CP electrodes overlaps in time at the patient'"'"'s spinal cord and/or brain stem with Aδ

/C fiber input from the NL electrodes.

2. The method of claim 1, wherein the step of applying electrical stimulation to the patient'"'"'s skin comprises:

utilizing at least one first CP electrode as a reference electrode for the NL electrodes while the NL electrodes apply electrical stimulation to cutaneous Aδ

/C fibers; and

utilizing at least one second CP electrode to apply electrical stimulation to cutaneous Aβ

fibers.

3. The method of claim 2, wherein the step of applying electrical stimulation to the patient'"'"'s skin comprises applying Cutaneous Field Stimulation (CFS) via the NL electrodes and applying Transcutaneous Electrical Nerve Stimulation (TENS) via the at least one second CP electrode.

4. The method of claim 1, wherein the step of applying electrical stimulation to the patient'"'"'s skin comprises applying electrical stimulation to the patient'"'"'s skin via at least one CP electrode and at least on neighboring NL electrode that are phase-locked such that signals produced in Aβ

fibers will arrive at the patient'"'"'s spinal cord prior to and overlapping in time with signals produced in slower conducting Aδ

/C fibers.

5. The method of claim 1, wherein the step of applying electrical stimulation to the patient'"'"'s skin comprises applying electrical stimulation to the patient'"'"'s skin in a pattern via individually paired or paired rows of CP electrodes and NL electrodes.

6. The method of claim 5, wherein the pattern causes a sensation of a sweeping stimulation that resembles that of scratching or massaging the patient'"'"'s skin.

7. The method of claim 1, wherein the step of applying electrical stimulation to the patient'"'"'s skin causes a sensation of a sweeping stimulation that resembles that of scratching or massaging the patient'"'"'s skin.

8. The method of claim 1, wherein the step of applying electrical stimulation to the patient'"'"'s skin increases vascularisation of the patient'"'"'s skin for cosmetic purposes or speeds up healing of wounds on the patient'"'"'s skin.

9. The method of claim 1, wherein the step of applying electrical stimulation to the patient'"'"'s skin comprising utilizing the electrical stimulation applied via the CP electrodes to generate a masking effect on an aversive effect of the electrical stimulation applied via the NL electrodes.

10. The method of claim 1, wherein the step of applying electrical stimulation to the patient'"'"'s skin comprises providing current to the CP electrodes with pulse trains having:

a burst frequency of 0.1 Hz to 10 Hz;

an internal frequency of 50 Hz to 400 Hz;

a burst length per CP electrode up to 100 ms;

a pulse duration of 0.05 ms to 0.3 ms; and

a current amplitude up to 50 mA.

11. The method of claim 10, wherein the step of applying electrical stimulation to the patient'"'"'s skin further comprises providing current to the NL electrodes with single pulses having:

a frequency of 0.1 Hz to 10 Hz;

a pulse duration of 0.5 to 10.0 ms; and

a current amplitude up to 2 mA.

12. The method of claim 1, further comprising at least one of the steps of:

attaching the CP electrodes to the front face of the electrode plate prior to the step of applying electrical stimulation to the patient'"'"'s skin; and

removing the CP electrodes from the front face of the electrode plate after the step of applying electrical stimulation to the patient'"'"'s skin.

13. The method of claim 1, wherein the abutting relationship causes the NL electrodes to penetrate through the epidermis of the patient'"'"'s skin a depth of 0.1 to 10 mm or more.

14. The method of claim 1, wherein the abutting relationship causes the CP electrodes to abut the epidermis of the patient'"'"'s skin.

15. The method of claim 1, wherein the step of mounting the electrode plate on the patient'"'"'s skin includes applying an adhesive to the front face of the electrode plate to maintain the front face in the abutting relationship with the patient'"'"'s skin.

16. The method of claim 15, wherein the adhesive is conductive and is disposed between the CP electrodes and the epidermis of the patient'"'"'s skin to enhance electrically conducting contact of the CP electrodes with the patient'"'"'s skin.

17. The method of claim 1, wherein

the step of providing an electrode plate includes providing an electrode plate with raised portions and depressions therebetween;

and

the step of mounting the electrode plate on a patient'"'"'s skin includes temporarily flattening the raised portions to allow the depressions therebetween to contact the patient'"'"'s skin.

18. The method of claim 17, wherein each raised portion is configured to carry a single NL electrode or a row of NL electrodes.

19. A method of stimulating sensory nerves comprising:

providing an electrode plate with a pattern of needle-like (NL) electrodes and conductive plate (CP) electrodes disposed on a front face of the plate element, the NL electrodes being configured to apply electrical stimulation to cutaneous Aδ

/C fibers, and the CP electrodes being configured to apply electrical stimulation to cutaneous Aβ

fibers;

providing a stimulator configured to apply electrical stimulation to cutaneous Aδ

/C fibers via the NL electrodes and to apply electrical stimulation to cutaneous Aβ

fibers via the CP electrodes, the stimulator being in separate electrical communication with the NL electrodes and the CP electrodes so a first type of electrical stimulation can be applied via the NL electrodes concurrently with a second type of electrical stimulation being applied via the CP electrodes;

mounting the electrode plate on a patient'"'"'s skin with the front face in an abutting relationship with the patient'"'"'s skin, the abutting relationship causing the NL electrodes to penetrate through the epidermis of the patient'"'"'s skin;

applying electrical stimulation to the patient'"'"'s skin via the pattern of NL electrodes and CP electrodes, the electrical stimulation being applied so that Aβ

fiber input from the CP electrodes overlaps in time at the patient'"'"'s spinal cord and/or brain stem with Aδ

/C fiber input from the NL electrodes.

20. The method of claim 19, wherein the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin, which comprises:

utilizing at least one first CP electrode as a reference electrode for the NL electrodes while the NL electrodes apply electrical stimulation to cutaneous Aδ

/C fibers; and

utilizing at least one second CP electrode to apply electrical stimulation to cutaneous Aβ

fibers.

21. The method of claim 20, wherein

the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin, which comprises applying the first type of electrical stimulation and the second type of electrical stimulation;

the first type of electrical stimulation is Cutaneous Field Stimulation (CFS); and

the second type of electrical stimulation is Transcutaneous Electrical Nerve Stimulation (TENS).

22. The method of claim 19, wherein the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin, which comprises applying electrical stimulation to the patient'"'"'s skin via at least one CP electrode and at least on neighboring NL electrode that are phase-locked such that signals produced in Aβ

fibers will arrive at the patient'"'"'s spinal cord prior to and overlapping in time with signals produced in slower conducting Aδ

/C fibers.

23. The method of claim 19, wherein the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin, which comprises applying electrical stimulation to the patient'"'"'s skin in a pattern via individually paired or paired rows of CP electrodes and NL electrodes.

24. The method of claim 23, wherein the pattern causes a sensation of a sweeping stimulation that resembles that of scratching or massaging the patient'"'"'s skin.

25. The method of claim 19, wherein the step of applying electrical stimulation to the patient'"'"'s skin increases vascularisation of the patient'"'"'s skin for cosmetic purposes or speeds up healing of wounds on the patient'"'"'s skin.

26. The method of claim 19, wherein

the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin;

and

the step of applying electrical stimulation to the patient'"'"'s skin causes a sensation of a sweeping stimulation that resembles that of scratching or massaging the patient'"'"'s skin.

27. The method of claim 19, wherein the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin, which comprises utilizing the electrical stimulation applied via the CP electrodes to generate a masking effect on an aversive effect of the electrical stimulation applied via the NL electrodes.

28. The method of claim 19, wherein the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin, which comprises providing current to the CP electrodes with pulse trains having:

a burst frequency of 0.1 Hz to 10 Hz;

an internal frequency of 50 Hz to 400 Hz;

a burst length per CP electrode up to 100 ms;

a pulse duration of 0.05 ms to 0.3 ms; and

a current amplitude up to 50 mA.

29. The method of claim 28, wherein the step of applying electrical stimulation to the patient'"'"'s skin further comprises providing current to the NL electrodes with single pulses having:

a frequency of 0.1 Hz to 10 Hz;

a pulse duration of 0.5 to 10.0 ms; and

a current amplitude up to 2 mA.

30. A method of stimulating sensory nerves comprising:

providing an electrode plate with a pattern of needle-like (NL) electrodes and flat conductive plate (CP) electrodes disposed on a front face of the electrode plate, the NL electrodes being configured to apply electrical stimulation to cutaneous thin Aδ

/C fibers, and the CP electrodes being configured to apply electrical stimulation to cutaneous large Aβ

fibers, and each of the CP electrodes being physically spaced and electrically separate from any needle-like protrusions on the front face of the plate element, wherein the needle-like protrusions include the NL electrodes;

mounting the electrode plate on a patient'"'"'s skin with the front face in an abutting relationship with the patient'"'"'s skin, the abutting relationship causing the NL electrodes to penetrate the epidermis of the patient'"'"'s skin; and

applying electrical stimulation to the patient'"'"'s skin via the pattern of NL electrodes and CP electrodes, the electrical stimulation being applied so that large Aβ

fiber input from the CP electrodes overlaps in time at the patient'"'"'s spinal cord and/or brain stem with thin Aδ

/C fiber input from the NL electrodes.

31. The method of claim 30, wherein the step of applying electrical stimulation to the patient'"'"'s skin comprises:

utilizing at least one first CP electrode as a reference electrode for the NL electrodes while the NL electrodes apply electrical stimulation to cutaneous thin Aδ

/C fibers; and

utilizing at least one second CP electrode to apply electrical stimulation to cutaneous large Aβ

fibers.

32. The method of claim 31, wherein the step of applying electrical stimulation to the patient'"'"'s skin comprises applying Cutaneous Field Stimulation (CFS) via the NL electrodes and applying Transcutaneous Electrical Nerve Stimulation (TENS) via the at least one second CP electrode.

33. The method of claim 30, wherein the step of applying electrical stimulation to the patient'"'"'s skin comprises applying electrical stimulation to the patient'"'"'s skin via at least one CP electrode and at least on neighboring NL electrode that are phase-locked such that signals produced in Aβ

fibers will arrive at the patient'"'"'s spinal cord prior to and overlapping in time with signals produced in slower conducting Aδ

/C fibers.

34. The method of claim 30, wherein the step of applying electrical stimulation to the patient'"'"'s skin comprises applying electrical stimulation to the patient'"'"'s skin in a pattern via individually paired or paired rows of CP electrodes and NL electrodes.

35. The method of claim 34, wherein the pattern causes a sensation of a sweeping stimulation that resembles that of scratching or massaging the patient'"'"'s skin.

36. The method of claim 30, wherein the step of applying electrical stimulation to the patient'"'"'s skin causes a sensation of a sweeping stimulation that resembles that of scratching or massaging the patient'"'"'s skin.

37. The method of claim 30, wherein the step of applying electrical stimulation to the patient'"'"'s skin increases vascularisation of the patient'"'"'s skin for cosmetic purposes or speeds up healing of wounds on the patient'"'"'s skin.

38. The method of claim 30, wherein the step of applying electrical stimulation to the patient'"'"'s skin comprises utilizing the electrical stimulation applied via the CP electrodes to generate a masking effect on an aversive effect of the electrical stimulation applied via the NL electrodes.

39. The method of claim 30, wherein the step of applying electrical stimulation to the patient'"'"'s skin comprises providing current to the CP electrodes with pulse trains having:

a burst frequency of 0.1 Hz to 10 Hz;

an internal frequency of 50 Hz to 400 Hz;

a burst length per CP electrode up to 100 ms;

a pulse duration of 0.05 ms to 0.3 ms; and

a current amplitude up to 50 mA.

40. The method of claim 39, wherein the step of applying electrical stimulation to the patient'"'"'s skin further comprises providing current to the NL electrodes with single pulses having:

a frequency of 0.1 Hz to 10 Hz;

a pulse duration of 0.5 to 10.0 ms; and

a current amplitude up to 2 mA.

41. The method of claim 30, further comprising at least one of the steps of:

attaching the CP electrodes to the front face of the electrode plate prior to the step of applying electrical stimulation to the patient'"'"'s skin; and

removing the CP electrodes from the front face of the electrode plate after the step of applying electrical stimulation to the patient'"'"'s skin.

42. The method of claim 30, wherein the abutting relationship causes the NL electrodes to penetrate through the epidermis of the patient'"'"'s skin a depth of 0.1 to 10 mm or more.

43. The method of claim 30, wherein the abutting relationship causes the CP electrodes to abut the epidermis of the patient'"'"'s skin.

44. The method of claim 30, wherein the step of mounting the electrode plate on the patient'"'"'s skin includes applying an adhesive to the front face of the electrode plate to maintain the front face in the abutting relationship with the patient'"'"'s skin.

45. The method of claim 44, wherein the adhesive is conductive and is disposed between the CP electrodes and the epidermis of the patient'"'"'s skin to enhance electrically conducting contact of the CP electrodes with the patient'"'"'s skin.

46. The method of claim 30, wherein

the step of providing an electrode plate includes providing an electrode plate with raised portions and depressions therebetween;

and

the step of mounting the electrode plate on a patient'"'"'s skin includes temporarily flattening the raised portions to allow the depressions therebetween to contact the patient'"'"'s skin.

47. The method of claim 46, wherein each raised portion is configured to carry a single NL electrode or a row of NL electrodes.

48. A method of stimulating sensory nerves comprising:

providing an electrode plate with a pattern of needle-like (NL) electrodes and conductive plate (CP) electrodes disposed on a front face of the electrode plate, the NL electrodes being configured to apply electrical stimulation to cutaneous thin Aδ

/C fibers, and the CP electrodes being configured to apply electrical stimulation to cutaneous large Aβ

fibers, and each of the CP electrodes being physically spaced and electrically separate from any needle-like protrusions on the front face of the plate element, wherein the needle-like protrusions include the NL electrodes;

providing a stimulator configured to apply electrical stimulation to cutaneous thin Aδ

/C fibers via the NL electrodes and to apply electrical stimulation to cutaneous large Aβ

fibers via the CP electrodes, the stimulator being in separate electrical communication with the NL electrodes and the CP electrodes so a first type of electrical stimulation can be applied via the NL electrodes concurrently with a second type of electrical stimulation being applied via the CP electrodes;

mounting the electrode plate on a patient'"'"'s skin with the front face in an abutting relationship with the patient'"'"'s skin, the abutting relationship causing the NL electrodes to penetrate through the epidermis of the patient'"'"'s skin; and

applying electrical stimulation to the patient'"'"'s skin via the pattern of NL electrodes and CP electrodes, the electrical stimulation being applied so that Aβ

fiber input from the CP electrodes overlaps in time at the patient'"'"'s spinal cord and/or brain stem with Aδ

/C fiber input from the NL electrodes.

49. The method of claim 48, wherein the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin, which comprises:

utilizing at least one first CP electrode as a reference electrode for the NL electrodes while the NL electrodes apply electrical stimulation to cutaneous thin Aδ

/C fibers; and

utilizing at least one second CP electrode to apply electrical stimulation to cutaneous large Aβ

fibers.

50. The method of claim 49, wherein

the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin, which comprises applying the first type of electrical stimulation and the second type of electrical stimulation;

the first type of electrical stimulation is Cutaneous Field Stimulation (CFS); and

the second type of electrical stimulation is Transcutaneous Electrical Nerve Stimulation (TENS).

51. The method of claim 48, wherein the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin, which comprises applying electrical stimulation to the patient'"'"'s skin via at least one CP electrode and at least one neighboring NL electrode that are phase-locked such that signals produced in Aβ

fibers will arrive at the patient'"'"'s spinal cord prior to and overlapping in time with signals produced in slower conducting Aδ

/C fibers.

52. The method of claim 48, wherein the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin, which comprises applying electrical stimulation to the patient'"'"'s skin in a pattern via individually paired or paired rows of CP electrodes and NL electrodes.

53. The method of claim 52, wherein the pattern causes a sensation of a sweeping stimulation that resembles that of scratching or massaging the patient'"'"'s skin.

54. The method of claim 48, wherein the step of applying electrical stimulation to the patient'"'"'s skin increases vascularisation of the patient'"'"'s skin for cosmetic purposes or speeds up healing of wounds on the patient'"'"'s skin.

55. The method of claim 48, wherein

the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin;

and

the step of applying electrical stimulation to the patient'"'"'s skin causes a sensation of a sweeping stimulation that resembles that of scratching or massaging the patient'"'"'s skin.

56. The method of claim 48, wherein the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin, which comprises utilizing the electrical stimulation applied via the CP electrodes to generate a masking effect on an aversive effect of the electrical stimulation applied via the NL electrodes.

57. The method of claim 48, wherein the stimulator is programmed to perform the step of applying electrical stimulation to the patient'"'"'s skin, which comprises providing current to the CP electrodes with pulse trains having:

a burst frequency of 0.1 Hz to 10 Hz;

an internal frequency of 50 Hz to 400 Hz;

a burst length per CP electrode up to 100 ms;

a pulse duration of 0.05 ms to 0.3 ms; and

a current amplitude up to 50 mA.

58. The method of claim 57, wherein the step of applying electrical stimulation to the patient'"'"'s skin further comprises providing current to the NL electrodes with single pulses having:

a frequency of 0.1 Hz to 10 Hz;

a pulse duration of 0.5 to 10.0 ms; and

a current amplitude up to 2 mA.