Medical electrode, electrode bundle and electrode bundle array

• US 8,386,006 B2
• Filed: 12/03/2008
• Issued: 02/26/2013
• Est. Priority Date: 12/10/2007
• Status: Active Grant

• Current Assignee: Neuronano AB
• Original Assignee: Neuronano AB
• Inventors: Schouenborg, Jens
• Primary Examiner(s): Cohen, Lee S
• Application Number:
  US12/747,343
• Publication Number:
  US 20110009728A1
• Time in Patent Office: 1,546 Days
• Field of Search: 600/373, 600/377, 600/378, 607/116
• US Class Current: 600/373
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor

Abstract

A medical microelectrode includes portions capable of movement relative to each other when implanted in or inserted into soft tissue, so as to increase or decrease their distance along the electrode. The electrode is at least partially embedded in a substantially rigid biocompatible matrix that is soluble or biodegradable a body fluid. Also disclosed are uses of the microelectrode; microelectrode bundles and arrays of microelectrode bundles and their uses; methods for inserting or implanting microelectrodes, microelectrode bundles and arrays of microelectrode bundles in soft tissue.

Claims

1. A medical electrode comprising:

a base section,

a tip section,

an electrode body disposed between the base section and the tip section,

the electrode body including one of;

(a) an electrically conducting core and an insulating layer on the core, or

(b) an electrically non-conducting core, an electrically conducting layer on the core and an insulating layer on the electrically conducting layer;

the electrode body further including portions configured for movement relative to each other when implanted in or inserted into soft tissue, so as to increase or decrease their distance along the electrode, and

a substantially rigid biocompatible matrix that is soluble or biodegradable in a body fluid, at least the tip section and the electrode body embedded in the matrix, the matrix forming a matrix body of a shape configured to follow a straight insertion track line when inserting the electrode deep into soft tissue.

2. The electrode of claim 1, wherein the base section, tip section, electrode body and substantially rigid biocompatible matrix form the matrix body.

3. The electrode of claim 2, wherein the electrode body comprises one or several passages through the insulating layer perpendicular to the core permitting electrical contact with the electrically conducting core or the electrically conducting layer.

4. The electrode of claim 2, wherein the electrode body is embedded in the matrix in a configuration in which its length is greater by 2 percent or more than the distance between its ends.

5. The electrode of claim 1, further comprising an anchor disposed at the tip section.

6. The electrode of claim 5, wherein the anchor is embedded in the matrix.

7. The electrode of claim 1, wherein the matrix body comprises two sections differing in their dissolution or degradation rate.

8. The electrode of claim 1, wherein a diameter of the electrode body is from about 10⁻

7 to about 10<sup>−

4</sup> m.

9. The electrode of claim 1, further comprising a dissolution retardation coating on the matrix body.

22. A method of inserting or implanting a flexible medical electrode in tissue in a desired configuration, comprising:

providing the electrode of claim 1;

inserting or implanting the electrode into/in tissue;

allowing the matrix to dissolve or to be degraded in situ.

10. A medical electrode bundle comprising:

two or more bundle electrodes, each bundle electrode including;

base section,

a tip section,

an electrode body disposed between the base section and the tip section,

the electrode body including one of;

(a) an electrically conducting core and an insulating layer on the core, or

(b) an electrically non-conducting core, an electrically conducting layer on the core and an insulating layer on the electrically conducting layer; and

portions of the electrode body configured for movement relative to each other when implanted in or inserted into soft tissue, so as to increase or decrease their distance along the electrode, and

a substantially rigid biocompatible matrix that is soluble or biodegradable in a body fluid, at least the tip section and the electrode body embedded in the matrix, the matrix forming a bundle matrix body of a shape configured to follow a straight insertion track line when inserting the electrode deep into soft tissue.

11. The electrode bundle of claim 10, wherein the body fluid is an aqueous body fluid.

12. The electrode bundle of claim 11, wherein each bundle electrode comprises an anchor disposed at the tip section.

13. The electrode bundle of claim 10, wherein the bundle matrix comprises two sections differing in their dissolution or degradation rate.

14. The electrode bundle of claim 10, wherein the electrode body is embedded in the bundle matrix in a configuration in which its length is greater by 2 percent than the distance between its ends.

15. The electrode bundle of claim 10, wherein the diameter of the electrode body is from about 10⁻

7 m to about 10<sup>−

4</sup> m.

16. The electrode bundle of claim 10, further comprising a dissolution retardation coating on the bundle matrix body.

17. The electrode bundle of claim 10, further comprising a base plate of a non-conducting material at which bases of bundle electrodes are mounted.

18. The electrode bundle of claim 10, comprising one or more optical fibres.

19. A medical electrode bundle array comprising two or more electrode bundles of claim 10, at least partially embedded in a substantially rigid biocompatible array matrix that is soluble or biodegradable in a body fluid, the array matrix foaming an array matrix body of a shape permitting following of a straight insertion track line when inserting the array deep into soft tissue.

20. The array of claim 19, wherein the dissolution or degradation rate of the array matrix in said body fluid is higher than the dissolution or degradation rate of the bundle matrix in the same fluid.

21. The array of claim 19, comprising a dissolution or degradation retardation coating on the array matrix body.

23. A method of inserting or implanting a medical electrode bundle in tissue in a desired configuration, comprising:

providing the electrode bundle of claim 10;

inserting or implanting the matrix embedded electrode bundle into/in tissue;

allowing the matrix to dissolve or be degraded in situ.

24. The method of claim 23, wherein the matrix comprises a proximal section of lower dissolution or degradation rate and a distal section of higher dissolution or degradation rate.

25. A method of inserting or implanting an array of medical electrode bundles comprising:

providing an array of electrode bundles of claim 19;

inserting the array into tissue; and

allowing the array and bundle matrices to dissolve or be degraded in situ.