Screening test for recognizing prostate diseases and apparatus and diagnosis substance for carrying out the test
First Claim
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1. A screening test method to detect a prostate disease, comprising the steps of:
- providing a diagnostic substance containing at least one biomarker connected with at least one ferromagnetic particle, said biomarker binding specifically to a target molecule that is formed by a specific pathological prostate tissue;
administering said diagnostic substance to the blood stream of a patient;
with a non-imaging magnetic sensor, measuring a level of enrichment of said ferromagnetic particles bound by said biomarker to said target molecule in the prostate of the patient by acquiring a first measurement value with said non-imaging magnetic sensor before said diagnostic substance reaches the prostate in the patient via said blood stream, and acquiring a second measurement value with said non-imaging magnetic sensor after measurement of a peak value occurring due to arrival of the diagnostic substance in the prostate of the subject has decayed to a substantially constant value; and
in a measurement apparatus supplied with the level of enrichment measured by said non-imaging magnetic sensor, automatically calculating a numerical level of said specific pathological prostate tissue in the patient by calculating a difference between said first measurement and said second measurement, and using said peak value as a third measurement value and calculating a difference between said third measurement value and said first measurement value, and using a quotient of the difference between said third measurement value and said first measurement value, and the difference between said first measurement value and said second measurement value, as said numerical level of pathological prostate tissue, and making said numerical level available in electronic form at an output of said measurement apparatus.
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Abstract
In a screening test method, and a device for implementing the screening test method, a diagnostic substance is provided that contains at least one biomarker connected with at least one ferromagnetic particle, the biomarker binding specifically to a target molecule that is formed by specific pathological prostrate tissue. The diagnostic substance is administered to the blood stream of a patient. A magnetometer is used to detect enrichment of the ferromagnetic particle in the prostrate, as an indicator of a level of the specific pathological prostrate tissue.
11 Citations
11 Claims
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1. A screening test method to detect a prostate disease, comprising the steps of:
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providing a diagnostic substance containing at least one biomarker connected with at least one ferromagnetic particle, said biomarker binding specifically to a target molecule that is formed by a specific pathological prostate tissue; administering said diagnostic substance to the blood stream of a patient; with a non-imaging magnetic sensor, measuring a level of enrichment of said ferromagnetic particles bound by said biomarker to said target molecule in the prostate of the patient by acquiring a first measurement value with said non-imaging magnetic sensor before said diagnostic substance reaches the prostate in the patient via said blood stream, and acquiring a second measurement value with said non-imaging magnetic sensor after measurement of a peak value occurring due to arrival of the diagnostic substance in the prostate of the subject has decayed to a substantially constant value; and in a measurement apparatus supplied with the level of enrichment measured by said non-imaging magnetic sensor, automatically calculating a numerical level of said specific pathological prostate tissue in the patient by calculating a difference between said first measurement and said second measurement, and using said peak value as a third measurement value and calculating a difference between said third measurement value and said first measurement value, and using a quotient of the difference between said third measurement value and said first measurement value, and the difference between said first measurement value and said second measurement value, as said numerical level of pathological prostate tissue, and making said numerical level available in electronic form at an output of said measurement apparatus. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification