Skin permeation device for analyte sensing or transdermal drug delivery
First Claim
1. A controlled abrasion device comprising a hand piece, an abrasive tip, a feedback control mechanism, and an electrical motor,wherein the abrasive tip does not contain a micro-needle,wherein the feedback control mechanism comprises (a) a source electrode, (b) a return electrode and (c) a controller,wherein the source electrode is located in the abrasive tip,wherein the return electrode is located at the proximal end of the hand piece,wherein the abrasive tip connects directly or indirectly to the motor such that the motor is able to cause the abrasive tip to move, and wherein the abrasive tip is attachable to and removable from the proximal end of the hand piece, andwherein the source electrode and the return electrode are in electrical communication with the controller, andwherein the feedback control mechanism measures the conductance through the skin in real time and calculates in real time the rate of change in the conductance over time when the device is applied to the skin to control the level of skin abrasion.
1 Assignment
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Accused Products
Abstract
Devices, systems, kits and methods for increasing the skin'"'"'s permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin'"'"'s permeability requires applying the controlled abrasion device to a portion of the skin'"'"'s surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.
234 Citations
26 Claims
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1. A controlled abrasion device comprising a hand piece, an abrasive tip, a feedback control mechanism, and an electrical motor,
wherein the abrasive tip does not contain a micro-needle, wherein the feedback control mechanism comprises (a) a source electrode, (b) a return electrode and (c) a controller, wherein the source electrode is located in the abrasive tip, wherein the return electrode is located at the proximal end of the hand piece, wherein the abrasive tip connects directly or indirectly to the motor such that the motor is able to cause the abrasive tip to move, and wherein the abrasive tip is attachable to and removable from the proximal end of the hand piece, and wherein the source electrode and the return electrode are in electrical communication with the controller, and wherein the feedback control mechanism measures the conductance through the skin in real time and calculates in real time the rate of change in the conductance over time when the device is applied to the skin to control the level of skin abrasion.
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13. A method for reducing the impedance of a tissue site comprising
applying an abrasive tip of a controlled abrasion device to the tissue site, wherein the device comprises a hand piece, the abrasive tip, a feedback control mechanism, and an electrical motor, wherein the feedback control mechanism comprises (a) a source electrode, (b) a return electrode and (c) a controller, wherein the source electrode is located in the abrasive tip, and wherein the return electrode is located at the proximal end of the hand piece, wherein the abrasive tip connects directly or indirectly to the motor such that the motor is able to cause the abrasive tip to move, wherein the abrasive tip is attachable to and removable from the proximal end of the hand piece, and wherein the abrasive tip does not contain a micro-needle, wherein the source electrode and the return electrode are in electrical communication with the controller, and wherein the feedback control mechanism measures the conductance through the skin in real time and calculates in real time the rate of change in the conductance over time when the device is applied to the skin to control the level of skin abrasion, turning the electrical motor on, and measuring an electrical parameter of the tissue site.
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24. A kit for reducing the impedance of a tissue site comprising a controlled abrasion device and at least one abrasive tip,
wherein the abrasion device comprises a hand piece, a feedback control mechanism, and an electrical motor, wherein the feedback control mechanism comprises (a) a source electrode, (b) a return electrode and (c) a controller, wherein the return electrode is located at the proximal end of the hand piece, wherein the abrasive tip connects directly or indirectly to the motor such that the motor is able to cause the abrasive tip to move, and wherein the abrasive tip is attachable to and removable from the proximal end of the hand piece, and wherein the source electrode and the return electrode are in electrical communication with the controller, and wherein the feedback control mechanism measures the conductance through the skin in real time and calculates in real time the rate of change in the conductance over time when the device is applied to the skin to control the level of skin abrasion, and wherein the abrasive tip comprises an abrasive material and the source electrode, and wherein the abrasive tip does not contain a micro-needle.
Specification