Iontophoresis device

• US 8,386,030 B2
• Filed: 08/08/2006
• Issued: 02/26/2013
• Est. Priority Date: 08/08/2005
• Status: Expired due to Fees

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Inventors: Kanamura, Kiyoshi, Kosiba, Nobuharu, Nakayama, Mizuo, Matsumura, Takehiko, Akiyama, Hidero, Matsumura, Akihiko
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): HOLLOWAY, IAN KNOBEL
• Application Number:
  US11/501,672
• Publication Number:
  US 20070060859A1
• Time in Patent Office: 2,394 Days
• Field of Search: 424/449, 604/20, 604/501
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

An iontophoresis device including an active electrode assembly or a counter electrode assembly with a polarizable electrode containing any one of a conductive material having a capacitance per unit weight of 1 F/g or greater, a conductive material having a specific surface area of 10 m2/g or greater, and activated carbon is disclosed. The generation of gas or ions due to an electrode reaction occurring in an electrode assembly may be reduced or prevented. In addition, the alteration of an active agent due to a chemical reaction upon energization may be reduced or prevented.

Claims

1. An iontophoresis device for administering active agent ions to a living body, comprising:

an electrolyte solution holding part to hold an electrolyte solution comprising a plurality of first electrolytic ions of a first polarity and a plurality of second electrolytic ions of a second polarity opposite to the first polarity; and

an electrode assembly comprising a polarized electrode, the polarized electrode comprising an electrical double layer, the electrical double layer including a conductive material having a capacitance per unit weight of 1 F/g or greater.

2. The iontophoresis device according to claim 1 wherein the polarized electrode is impregnatable with the electrolyte solution.

3. The iontophoresis device according to claim 1 wherein the polarized electrode is blended with a binder polymer.

4. The iontophoresis device according to claim 1 wherein:

the electrode assembly further comprises a collector having an outer surface side; and

the polarized electrode is located on the outer surface side of the collector.

5. The iontophoresis device according to claim 1 wherein the electrode assembly further comprises an active agent solution reservoir for holding an active agent solution containing an active agent ion, the active agent solution reservoir located on an outer surface side of the polarized electrode.

6. The iontophoresis device according to claim 1 wherein the electrode assembly further comprises a first ion exchange membrane comprising an active agent ion, the first ion exchange membrane located on an outer surface side of the polarized electrode.

7. An iontophoresis device, comprising:

an electrode assembly comprising a polarized electrode, the polarized electrode comprising an electrical double layer, the electrical double layer including a conductive material having a specific surface area of 10 m²/g or greater.

8. The iontophoresis device according to claim 7 wherein the polarized electrode holds an electrolyte solution.

9. The iontophoresis device according to claim 7 wherein the polarized electrode comprises a binder polymer.

10. The iontophoresis device according to claim 7 wherein:

the electrode assembly further comprises a collector having an outer surface side; and

the polarized electrode is located on the outer surface side of the collector.

11. The iontophoresis device according to claim 7 wherein the electrode assembly further comprises an active agent solution reservoir configured to hold an active agent solution containing an active agent ion, the active agent solution reservoir located on an outer surface side of the polarized electrode.

12. The iontophoresis device according to claim 11 wherein the polarized electrode holds an active agent solution having the same composition as that of an active agent solution in the active agent solution reservoir.

13. The iontophoresis device according to claim 12 wherein the electrode assembly further comprises a first ion exchange membrane comprising an active agent ion, the first ion exchange membrane located on the outer surface side of the polarized electrode.

14. The iontophoresis device according to claim 11 wherein the electrode assembly further comprises a first ion exchange membrane comprising an active agent ion, the first ion exchange membrane located on the outer surface side of the polarized electrode.

15. The iontophoresis device according to claim 7 wherein the electrode assembly further comprises a first ion exchange membrane comprising an active agent ion, the first ion exchange membrane located on an outer surface side of the polarized electrode.

16. An iontophoresis device, comprising:

an electrode assembly comprising a polarized electrode, the polarized electrode comprising an electrical double layer, the electrical double layer including activated carbon.

17. The iontophoresis device according to claim 16 wherein the polarized electrode holds an electrolyte solution.

18. The iontophoresis device according to claim 16 wherein the polarized electrode is blended with a binder polymer.

19. The iontophoresis device according to claim 18 wherein the binder polymer comprises polytetrafluoroethylene or polyvinylidene fluoride.

20. The iontophoresis device according to claim 18 wherein:

the electrode assembly further comprises a collector; and

the polarized electrode is located on an outer surface side of the collector.

21. The iontophoresis device according to claim 16 wherein:

the electrode assembly further comprises a collector; and

the polarized electrode is located on an outer surface side of the collector.

22. The iontophoresis device according to claim 21 wherein the electrode assembly further comprises an active agent solution reservoir configured to hold an active agent solution containing an active agent ion, the active agent solution reservoir located on the outer surface side of the polarized electrode.

23. The iontophoresis device according to claim 22 wherein the electrode assembly further comprises a first ion exchange membrane comprising an active agent ion, the first ion exchange membrane located on the outer surface side of the polarized electrode.

24. The iontophoresis device according to claim 21 wherein the collector comprises carbon fiber or carbon fiber paper.

25. The iontophoresis device according to claim 24 wherein the electrode assembly further comprises an active agent solution reservoir configured to hold an active agent solution containing an active agent ion, the active agent solution reservoir located on the outer surface side of the polarized electrode.

26. The iontophoresis device according to claim 25 wherein the electrode assembly further comprises a first ion exchange membrane comprising an active agent ion, the first ion exchange membrane located on an outer surface side of the polarized electrode.

27. The iontophoresis device according to claim 21 wherein the polarized electrode comprises a binder polymer.

28. The iontophoresis device according to claim 27 wherein the binder polymer comprises polytetrafluoroethylene or polyvinylidene fluoride.

29. The iontophoresis device according to claim 28 wherein the electrode assembly further comprises an active agent solution reservoir configured to hold an active agent solution containing an active agent ion, the active agent solution reservoir located on the outer surface side of the polarized electrode.

30. The iontophoresis device according to claim 29 wherein the electrode assembly further comprises a first ion exchange membrane comprising an active agent ion, the first ion exchange membrane located on the outer surface side of the polarized electrode.

31. The iontophoresis device according to claim 27 wherein the polarized electrode holds an electrolyte solution.

32. The iontophoresis device according to claim 16 wherein the activated carbon comprises an activated carbon fiber.

33. The iontophoresis device according to claim 32 wherein the activated carbon fiber is obtained by carbonizing and activating a novoloid fiber.

34. The iontophoresis device according to claim 32 wherein the polarized electrode holds an electrolyte solution.

35. The iontophoresis device according to claim 32 wherein the electrode assembly further comprises an active agent solution reservoir configured to hold an active agent solution containing an active agent ion, the active agent solution reservoir located on the outer surface side of the polarized electrode.

36. The iontophoresis device according to claim 35 wherein the electrode assembly further comprises a first ion exchange membrane comprising an active agent ion, the first ion exchange membrane located on an outer surface side of the polarized electrode.

37. The iontophoresis device according to claim 16 wherein the electrode assembly further comprises an active agent solution reservoir configured to hold an active agent solution containing an active agent ion, the active agent solution reservoir located on the outer surface side of the polarized electrode.

38. The iontophoresis device according to claim 37 wherein the electrode assembly further comprises a first ion exchange membrane comprising an active agent ion, the first ion exchange membrane located on the outer surface side of the polarized electrode.

39. The iontophoresis device according to claim 21 further comprising:

a terminal member comprising a conductive resin, the conductive resin comprising a polymer matrix and a carbon powder, the terminal member attached to the collector.

40. The iontophoresis device according to claim 21 wherein:

the polarized electrode is blended with a binder polymer; and

the collector is impregnated with a binder polymer.

41. The iontophoresis device according to claim 21 wherein the collector has a conductive sheet portion having a predetermined area and an extension formed integrally with the conductive sheet portion.

42. The iontophoresis device according to claim 21 wherein the collector comprises a coating film of a conductive paint containing a conductive powder.

43. The iontophoresis device according to claim 42 wherein the conductive powder comprises a carbon powder.

44. The iontophoresis device according to claim 21 wherein the collector and the polarized electrode are bonded to each other by using a conductive adhesive.

45. The iontophoresis device according to claim 21 wherein the collector is formed on a plastic substrate.

46. The iontophoresis device according to claim 21 wherein the electrode assembly further comprises an active agent solution reservoir configured to hold an active agent solution containing an active agent ion, the active agent solution reservoir located on the outer surface side of the polarized electrode.

47. The iontophoresis device according to claim 21 wherein the polarized electrode holds an active agent solution having the same composition as that of the active agent solution in the active agent solution reservoir.

48. The iontophoresis device according to claim 21 wherein the electrode assembly further comprises a first ion exchange membrane comprising an active agent ion, the first ion exchange membrane located on the outer surface side of the polarized electrode.

49. An iontophoresis device, comprising:

an active electrode assembly that holds an active agent ion of a first polarity;

a counter electrode assembly, the counter electrode assembly comprising a polarized electrode, the polarized electrode comprising an electrical double layer, the electrical double layer including a conductive material having a capacitance per unit weight of 1 F/g or greater; and

an ion exchange membrane located on an outer surface side of the polarized electrode.

50. An iontophoresis device, comprising:

an active electrode assembly that holds an active agent ion of a first polarity;

a counter electrode assembly, the counter electrode assembly comprising a polarized electrode, the polarized electrode comprising an electrical double layer, the electrical double layer including a conductive material having a specific surface area of 10 m²/g or greater; and

an ion exchange membrane located on an outer surface side of the polarized electrode.

51. An iontophoresis device, comprising:

an active electrode assembly that holds an active agent ion of a first polarity;

a counter electrode assembly, the counter electrode assembly comprising a polarized electrode, the polarized electrode comprising an electrical double layer, the electrical double layer including activated carbon; and

an ion exchange membrane located on an outer surface side of the polarized electrode.