Selective resonant reconfiguration of chemical structures

• US 8,386,183 B2
• Filed: 09/24/2007
• Issued: 02/26/2013
• Est. Priority Date: 07/21/2005
• Status: Expired due to Fees

• Current Assignee: Enterprise Science Fund, LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Ishikawa, Muriel Y., Jung, Edward K. Y., Leuthardt, Eric C., Myhrvold, Nathan P., Wood, Lowell L. Jr.
• Primary Examiner(s): Lin, Jerry
• Application Number:
  US11/904,044
• Publication Number:
  US 20080069738A1
• Time in Patent Office: 1,982 Days
• Field of Search: 702/19
• US Class Current: 702/19
• CPC Class Codes: A61K 31/4743 condensed with ring systems having sulfur as a ring hetero atom
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: A61N 2/00 Magnetotherapy
• CPC Class Codes: B01J 19/12 employing electromagnetic waves
• CPC Class Codes: B01J 19/121 Coherent waves, e.g. laser beams lasers per se H01S3/00
• CPC Class Codes: C07K 1/00 General methods for the preparation of peptides , i.e. processes for the organic chemical preparation of peptides or proteins of any length
• CPC Class Codes: C07K 2299/00 Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Abstract

Chemical compositions may be selectively or preferentially excited by the application of scores comprising a series of energy inputs, thereby changing them from a first geometric configuration to a second geometric configuration (e.g., a first to a second stereoisomer).

Claims

1. A method of exciting a composition including a plurality of resonant structures, each resonant structure having a respective resonant frequency, the method comprising:

selecting a set of excitation energies, each excitation energy having a respective amplitude and a respective frequency corresponding to the resonant frequency of at least one of the resonant structures of the plurality; and

applying the set of excitation energies to the composition, wherein;

the set of excitation energies, applied together, are selected to induce the composition to change from a first stereoisomer to a second stereoisomer; and

any one of the excitation energies, applied at its respective amplitude in the absence of the other members of the set, would not induce a substantial change from the first stereoisomer to the second stereoisomer.

2. The method of claim 1, wherein the frequency is a modulation frequency.

3. The method of claim 1, wherein the excitation energies are applied simultaneously.

4. The method of claim 1, wherein the excitation energies are applied sequentially.

5. The method of claim 1, wherein the excitation energies are applied in a temporally overlapping fashion.

6. The method of claim 1, wherein the composition is a biomolecule.

7. The method of claim 6, wherein the biomolecule is a protein or a nucleotide.

8. The method of claim 6, wherein the biomolecule is a therapeutic agent.

9. The method of claim 1, wherein the plurality of resonant structures comprises a longitudinal vibrational mode of a bond.

10. The method of claim 1, wherein the plurality of resonant structures comprises a bending mode of two bonds to an atom.

11. The method of claim 1, wherein the plurality of resonant structures comprises a squashing mode of a plurality of bonds.

12. The method of claim 1, wherein the excitation energies are electromagnetic beams.

13. The method of claim 12, wherein at least one of the electromagnetic beams is an infrared beam.

14. The method of claim 12, wherein at least one of the electromagnetic beams is amplitude modulated.

15. The method of claim 12, wherein at least one of the electromagnetic beams is frequency modulated.

16. The method of claim 12, further comprising scanning at least one of the electromagnetic beams.

17. The method of claim 12, wherein at least two of the electromagnetic beams intersect at a target location.

18. The method of claim 1, further comprising applying a field to the composition, wherein the field acts to preferentially orient at least one resonant structure.

19. The method of claim 1, wherein:

the plurality of resonant structures are in an arrangement having two end resonant structures and a center resonant structure; and

the set of excitation energies is applied in a sequence beginning from the excitation energies having frequencies matching the two end resonant structures and progressing towards the excitation energy having the frequency matching the center resonant structure.

20. The method of claim 1, wherein the composition is a crystal.

21. The method of claim 1, wherein the composition is a complex of molecules.

22. The method of claim 1, wherein the set of excitation energies comprises at least 4 excitation energies.

23. The method of claim 1, wherein the set of excitation energies comprises at least 10 excitation energies.

24. The method of claim 1, wherein the set of excitation energies comprises at least 36 excitation energies.

25. The method of claim 8, wherein the therapeutic agent is selected to modify clotting activity in blood.

26. The method of claim 12, wherein each electromagnetic beam has at least one characteristic selected from the group consisting of:

a selected set of frequencies;

a selected set of phases;

a selected set of amplitudes;

a selected temporal profile;

a selected set of polarizations; and

a selected direction.

27. The method of claim 26, wherein the selected set of frequencies is approximately monochromatic.

28. The method of claim 26, wherein the selected set of frequencies comprises a plurality of local maxima.

29. The method of claim 26, wherein the selected set of frequencies is approximately Gaussian.

30. The method of claim 26, wherein at least one of the electromagnetic beams is coherent.

31. The method of claim 26, wherein at least one of the electromagnetic beams is incoherent.

32. The method of claim 26, wherein the selected set of frequencies comprises at least two frequencies, and wherein the at least two frequencies have differing amplitudes.

33. The method of claim 26, wherein the temporal profile is characterized by a selected beam duration.

34. The method of claim 26, wherein the temporal profile is characterized by a selected change in frequency, phase, amplitude, polarization, or direction during a selected time interval.

35. The method of claim 26, wherein at least one of the electromagnetic beams is polarized.

36. The method of claim 12, wherein at least two of the electromagnetic beams differ in frequency, phase, amplitude, temporal profile, polarization or orientation.

37. The method of claim 18, wherein the field is selected from the group consisting of an electric field, a magnetic field, an electromagnetic field, a mechanical stress, a mechanical strain, a lowered or elevated temperature, a lowered or elevated pressure, a phase change, an adsorbing surface, a catalyst, an excitation energy, and combinations thereof.