Delivery devices and methods with collimated gas stream and particle source
First Claim
1. A delivery device for the delivery of particles into a biological tissue comprising:
- a housing;
a gas source comprising a gas or capable of selectively producing a gas;
a first particle source comprising a first plurality of particles;
a first collimator fluidly connected with the gas source and comprising a plurality of conduits adapted to form a first plurality of collimated streams of the first plurality of particles entrained in the gas; and
a tissue-interfacing surface located at one end of the housing and adapted to interface with a surface of the tissue and orient the first collimator with the tissue such that the first plurality of collimated streams of the first plurality of particles will penetrate the tissue in a direction substantially perpendicular to the surface of the tissue.
7 Assignments
0 Petitions
Accused Products
Abstract
Delivery devices, methods and systems are provided for the delivery of particles into a biological tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas; a first particle source comprising a first plurality of particles; a first collimator fluidly connected with the gas source and adapted to form a collimated stream of the first plurality of particles entrained in the gas. The device also includes a tissue-interfacing surface adapted to interface with a surface of the tissue and orient the first collimator with the tissue such that the collimated stream of the first plurality of particles will penetrate the tissue in a direction substantially perpendicular to the surface of the tissue.
-
Citations
20 Claims
-
1. A delivery device for the delivery of particles into a biological tissue comprising:
-
a housing; a gas source comprising a gas or capable of selectively producing a gas; a first particle source comprising a first plurality of particles; a first collimator fluidly connected with the gas source and comprising a plurality of conduits adapted to form a first plurality of collimated streams of the first plurality of particles entrained in the gas; and a tissue-interfacing surface located at one end of the housing and adapted to interface with a surface of the tissue and orient the first collimator with the tissue such that the first plurality of collimated streams of the first plurality of particles will penetrate the tissue in a direction substantially perpendicular to the surface of the tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A method of delivering particles into a biological tissue comprising:
-
delivering a pressurized gas into a plurality of conduits of a collimator to produce a plurality of streams of gas; and
thenreleasing a first plurality of particles into the plurality of streams of gas to produce a plurality of collimated streams of the first plurality of the particles entrained in the gas; and delivering the first plurality of particles through a surface of the tissue in a direction substantially perpendicular to the surface of the tissue. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
-
-
19. A drug delivery system for delivering a drug into a biological tissue comprising:
-
a particle delivery device for the delivery of particles into a tissue comprising; a housing; a gas source comprising a gas; a first particle source comprising a first plurality of particles; a first collimator fluidly connected with the gas source and comprising a plurality of conduits adapted to form a first plurality of collimated streams of the first plurality of particles entrained in the gas; and a tissue-interfacing surface located at one end of the housing and adapted to interface with a surface of the tissue and align the first collimator with the tissue such that the first plurality of collimated streams of the first plurality of particles will penetrate the tissue in a direction substantially perpendicular to the surface of the tissue; and a drug-delivery patch comprising a drug-permeable tissue-interfacing surface, a drug-impermeable backing layer, and a drug contained between the tissue-interfacing surface and the backing layer. - View Dependent Claims (20)
-
Specification