Method for determining hematocrit corrected analyte concentrations
First Claim
1. A method of determining a type of fluid sample applied to the test strip, the method comprising:
- providing a test strip having a reference electrode and a working electrode, wherein the working electrode is formed with a plurality of microelectrodes and is coated with a reagent layer;
applying a fluid sample to the test strip for a reaction period;
applying a test voltage between the reference electrode and the working electrode;
measuring a test current as a function of time;
measuring a steady state current value when the test current has reached an equilibrium;
calculating a ratio of the test current to the steady state current value;
plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time;
calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time;
determining a type of a fluid sample applied to the test strip by comparing a measured value for the effective diffusion coefficient against an acceptance range for a bodily fluid and a control solution; and
displaying an appropriate error message if the effective diffusion coefficient does not pass the acceptance range for the type of fluid sample applied to the test strip.
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Abstract
Description is provided herein for an embodiment of a method determining a hematocrit-corrected glucose concentration. The exemplary method includes providing a test strip having a reference electrode and a working electrode, wherein the working electrode includes a plurality of microelectrodes and is coated with at least an enzyme and a mediator. The method can be achieved by: providing a test strip comprising a reference electrode and a working electrode formed with a plurality of microelectrodes and coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.
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Citations
15 Claims
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1. A method of determining a type of fluid sample applied to the test strip, the method comprising:
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providing a test strip having a reference electrode and a working electrode, wherein the working electrode is formed with a plurality of microelectrodes and is coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; determining a type of a fluid sample applied to the test strip by comparing a measured value for the effective diffusion coefficient against an acceptance range for a bodily fluid and a control solution; and displaying an appropriate error message if the effective diffusion coefficient does not pass the acceptance range for the type of fluid sample applied to the test strip. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system comprising:
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a test strip having a reference electrode and a working electrode, wherein the working electrode formed with a plurality of microelectrodes and coated with an reagent layer and wherein the test strip further comprises an insulation portion disposed on the plurality of microelectrodes; and a test meter comprising; an electronic circuit for applying a test voltage between the reference electrode and the working electrode; and a signal processor for measuring a test current and for calculating an effective diffusion coefficient. - View Dependent Claims (12, 13, 14, 15)
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Specification