Coenzyme Q 10 -containing water-soluble composition and process for production thereof

• US 8,388,950 B2
• Filed: 06/14/2006
• Issued: 03/05/2013
• Est. Priority Date: 06/15/2005
• Status: Expired due to Fees

• Current Assignee: Kaneka Corporation
• Original Assignee: Kaneka Corporation
• Inventors: Ikehara, Toshinori, Kishida, Hideyuki
• Primary Examiner(s): Carlson, Karen Cochrane
• Assistant Examiner(s): MOSS, NATALIE M
• Application Number:
  US11/917,454
• Publication Number:
  US 20100284983A1
• Time in Patent Office: 2,456 Days
• Field of Search: None
• US Class Current: 424/94.1
• CPC Class Codes: A23K 20/174 Vitamins
• CPC Class Codes: A23L 29/10 containing emulsifiers
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 8/355 Quinones
• CPC Class Codes: A61K 8/39 Derivatives containing from 2 to 10 oxyalkylene groups
• CPC Class Codes: A61K 9/107 Emulsions ; Emulsion preconcentrates; Micelles composition of emulsions A61K47/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

A coenzyme Q₁₀-containing water soluble composition comprises coenzyme Q₁₀, a hydrophilic polyglycerol fatty acid ester, a lipophilic sucrose fatty acid ester and an aqueous phase component and a process for producing the same are disclosed. A coenzyme Q₁₀-containing water-soluble dry powder can be obtained by drying the above-mentioned coenzyme Q₁₀-containing water soluble composition. A food, functional food, beverage, pharmaceutical product, quasi drug, cosmetic, or animal food can be obtained by using the above-mentioned coenzyme Q₁₀-containing water soluble composition or the above-mentioned coenzyme Q₁₀-containing water-soluble dry powder. The coenzyme Q₁₀-containing water soluble composition has a high bioavailability, and maintains a stable emulsion form for a long period of time from refrigeration temperature to room temperature and allows efficient supply.

Claims

1. A coenzyme Q₁₀-containing water soluble composition which comprises coenzyme Q₁₀, a hydrophilic polyglycerol fatty acid ester, a lipophilic sucrose fatty acid ester, and an aqueous phase component,

wherein the hydrophilic polyglycerol fatty acid ester is a decaglycerol mon-saturated fatty acid ester constituted of a fatty acid residue containing 12 or more carbon atoms.

2. The coenzyme Q₁₀-containing water soluble composition according to claim 1, wherein the saturated fatty acid ester is at least one species selected from the group consisting of a laurate ester, a myristate ester and a palmitate ester.

3. The coenzyme Q₁₀-containing water soluble composition according to claim 1, wherein the lipophilic sucrose fatty acid ester is an ester composed of a higher fatty acid and acetic acid.

4. The coenzyme Q₁₀-containing water soluble composition according to claim 1, which comprises 0.01 to 40% by weight of coenzyme Q₁₀ in the whole water soluble composition.

5. The coenzyme Q₁₀-containing water soluble composition according to claim 1, wherein the content of the hydrophilic polyglycerol fatty acid ester is 1-10 to 500 parts by weight to 100 parts by weight of coenzyme Q₁₀.

6. The coenzyme Q₁₀-containing water soluble composition according to claim 1, wherein the content of the lipophilic sucrose fatty acid ester is 1 to 200 parts by weight to 100 parts by weight of coenzyme Q₁₀.

7. The coenzyme Q₁₀-containing water soluble composition according to claim 1, wherein the aqueous phase component is a polyhydric alcohol and/or water.

8. A coenzyme Q₁₀-containing water-soluble dry powder which is obtained by drying the coenzyme Q₁₀-containing water soluble composition according to claim 1.

9. A food, functional food, beverage, pharmaceutical product, quasi drug, cosmetic, or animal food which is obtained by using the coenzyme Q₁₀-containing water soluble composition according to claim 1 or which is obtained by using a coenzyme Q₁₀-containing water-soluble dry powder which is obtained by drying the coenzyme Q₁₀-containing water soluble composition according to claim 1.

10. The coenzyme Q₁₀-containing water soluble composition according to claim 1 which is an oil-in-water emulsion.

11. The coenzyme Q₁₀-containing water soluble composition according to claim 10, wherein the median size of emulsion particles in the water soluble composition is not larger than 100 nm.

12. The coenzyme Q₁₀-containing water soluble composition according to claim 1, wherein the aqueous phase component is a mixture of a polyhydric alcohol and water, and the polyhydric alcohol is selected from the group consisting of glycerol and sorbitol.