Fc variants
First Claim
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1. A method of mediating antibody-dependent cell-mediated cytotoxicity (ADCC) in a human comprising administering to a human a composition comprising a variant antibody of a parent antibody, wherein said variant comprises 239D/332E substitutions in the Fc region, wherein numbering is according to the EU index.
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Abstract
The present invention relates to Fc variants having increased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
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4 Claims
- 1. A method of mediating antibody-dependent cell-mediated cytotoxicity (ADCC) in a human comprising administering to a human a composition comprising a variant antibody of a parent antibody, wherein said variant comprises 239D/332E substitutions in the Fc region, wherein numbering is according to the EU index.
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