Ingestible implement for weight control

• US 8,389,003 B2
• Filed: 03/29/2007
• Issued: 03/05/2013
• Est. Priority Date: 03/29/2006
• Status: Active Grant

• Current Assignee: Eatlittle Incorporated
• Original Assignee: Eatlittle Incorporated
• Inventors: Mintchev, Martin Pavlov, Yadid-Pecht, Orly, Fattouche, Michel
• Primary Examiner(s): ZISKA, SUZANNE E
• Application Number:
  US12/294,659
• Publication Number:
  US 20100215732A1
• Time in Patent Office: 2,168 Days
• Field of Search: None
• US Class Current: 424/451
• CPC Class Codes: A61F 5/0036 Intragastrical devices
• CPC Class Codes: A61J 3/071 into the form of telescopically engaged two-piece capsules
• CPC Class Codes: A61K 9/0065 Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
• CPC Class Codes: A61K 9/009 Sachets, pouches characterised by the material or function of the envelope with gastric retention A61K9/0065; sachets which are not administered but function merely as a container are classified according to the content, e.g. sachets comprising powder for reconstitution of a drink A61K9/0095
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents

Abstract

An orally administrable implement for expanding in a stomach of an animal, including a mammal, to fill a space in the stomach, is provided for weight control. The implement includes: a fluid-permeable expandable container having a first dimension and a second dimension; and a plurality of clusters comprising a swellable material contained within the container and capable of swelling when contacted with a fluid; whereby when the implement is ingested, the fluid in the stomach enters the container causing the clusters therein to swell and the container to expand from the first dimension to the second dimension.

Claims

1. An orally administrable implement for expanding in a stomach of an animal, including a mammal, to fill a space in the stomach, comprising:

(a) a carrier;

(b) at least one fluid-permeable expandable container having a first size and a second size;

(c) a plurality of clusters contained within each container, each cluster comprising a swellable material and each cluster being capable of swelling when contacted with a fluid to expand each container from a first size to a second size; and

(d) a coupler for releasably coupling the at least one expandable container to the carrier;

whereby after a desired amount of time the plurality of clusters are individually released from each container in the stomach to now pass through the pylorus.

2. The orally administrable implement as claimed in claim 1, wherein when the at least one container is in has the first dimension size the orally administrable implement can be retained in an ingestible capsule.

3. The orally administrable implement as claimed in claim 1, wherein when the at least one container has the second size the implement will be of a sufficiently large size so as to be retained in the stomach.

4. The orally administrable implement as claimed in claim 1, wherein the coupler comprises a piece of absorbable biodegradable fiber or medical gauze for releasably attaching the at least one container to the carrier.

5. The orally administrable implement as claimed in claim 1, further comprising a built-in microelectronic system operably associated with the carrier, or the container, or both, for tracking the release of the at least one container.

6. The orally administrable implement as claimed in claim 1, further comprising a built-in microelectronic system operably associated with the carrier, or the container, or both, for tracking the animal including a mammal that has ingested the said implement.

7. The orally administrable implement as claimed in claim 1 further comprising at least one active agent releasably associated with either the at least one container, the clusters of swellable material, or both.

8. The orally administrable implement as claimed in claim 7, the at least one active agent is selected from the group consisting of enzymatic agents, medicinal agents, chemical agents, or combinations thereof.

9. The orally administrable implement as claimed in claim 1, further comprising a plurality of clusters comprising a substance-absorbable material contained within the at least one container and capable of absorbing the targeted substance present in the stomach.

10. The orally administrable implement as claimed in claim 9, wherein the substance-absorbing material is a lipid-absorbing material.

11. The orally administrable implement as claimed in claim 10, wherein the lipid-absorbing material is lipid-absorbing chitosan fiber, oxidized cellulose fiber, or a combination of both.

12. The orally administrable implement as claimed in claim 1, wherein the container is made from fiber comprising a substance-absorbing material.

13. The orally administrable implement as claimed in claim 12, wherein the substance-absorbing material is a lipid-absorbing material.

14. The orally administrable implement as claimed in claim 13, wherein the lipid-absorbing material is lipid-absorbing chitosan fiber, oxidized cellulose fiber, or a combination of both.

15. The orally administrable implement as claimed in claim 1, wherein the implement can be self-administrable in the case of humans or administrable autonomously.

16. The orally administrable implement as claimed in claim 1, wherein the swelled clusters do not exceed about 1.0 cm in diameter.

17. The orally administrable implement as claimed in claim 1, wherein the swelled clusters do not exceed about 0.6 cm in diameter.