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Formation of immobilized biological layers for sensing

  • US 8,389,042 B2
  • Filed: 05/23/2012
  • Issued: 03/05/2013
  • Est. Priority Date: 12/20/2007
  • Status: Expired due to Fees
First Claim
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1. A method of forming an immobilized layer on a sensor on a substantially planar surface comprising the steps of:

  • (a) dispensing a controlled volume of a photoformable matrix at a pre-selected location on said surface, wherein the photoformable matrix comprises a biologically active material selected from the group consisting of protein, enzyme, antibody, antibody fragment, RNA, single stranded DNA and double stranded DNA, an acrylic-based monomer, a water soluble organic photo-initiator and a water soluble acrylic-based cross-linker in an aqueous mixture; and

    (b) applying a UV radiation beam onto an area substantially covering said pre-selected location, starting at a predetermined time after said volume has been dispensed and for a predetermined duration at a predetermined intensity, to form said immobilized layer.

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