In situ self-setting mineral-polymer hybrid materials, composition and use thereof

• US 8,389,467 B2
• Filed: 10/08/2009
• Issued: 03/05/2013
• Est. Priority Date: 12/09/1999
• Status: Expired due to Fees

• Current Assignee: Smith & Nephew Orthopaedics Ag (Smith & Nephew PLC)
• Original Assignee: Piramal Healthcare Limited (Piramal Enterprises Limited)
• Inventors: Chaput, Cyril, Rodrigues El Zein, Anabelle
• Primary Examiner(s): Tate, Christopher R.
• Assistant Examiner(s): TELLER, ROY R
• Application Number:
  US12/575,765
• Publication Number:
  US 20100029549A1
• Time in Patent Office: 1,244 Days
• Field of Search: None
• US Class Current: 514/1.1
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 24/0063 Phosphorus containing materials, e.g. apatite
• CPC Class Codes: A61L 24/0084 containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
• CPC Class Codes: A61L 24/08 Polysaccharides A61L24/043 takes precedence
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/32 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/425 of phosphorus containing material, e.g. apatite
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

The present invention relates to self-setting compositions consisting in admixed liquid and solid components enable the formation of hardened bio-materials having a broad range of properties and performances. The present invention proposes a) a thermo-sensitive self-gelling liquid component, being water-based, comprising at least a polycationic and a phosphate source, wherein the liquid component is a thermo-gelling solution at a pH ranging from 6.5 to 7.4; b) a powder component consisting in at least two calcium phosphate sources. The preferred calcium phosphate source includes apatites, tricalcium phosphates, tetracalcium phosphates and dicalcium phosphates. Both solid and liquid components are admixed to form a flowable slurry that sets in situ into a hardened calcium phosphate based bio-material.

Claims

1. An injectable self-setting composition comprising:

a) a liquid component, free of insoluble material, comprising, an organic and/or inorganic acid, a partially N-deacetylated chitosan and/or a collagen, and a glycerophosphate salt;

said liquid component having a pH ranging from 6.5 to 7.4, said liquid component having an endothermally gelling character, said partially N-deacetylated chitosan having a final concentration ranging between 0.5 to 3.0% w/v, and said glycerophosphate salt having a final concentration ranging between 1.0 to 10.0% w/v, and

b) a powder component comprising a dry mixture of a tricalcium phosphate with a calcium deficient apatite or an octacalcium phosphate, and with at least one of an inorganic salt, an organic salt, an organic acid source and an organic compound,

wherein when said components of step a) and b) are intimately and uniformly mixed together, said components of step a) and b) form an injectable thermo-setting slurry, said slurry when heated turns into a solid material.

2. The composition as described in claim 1, wherein said inorganic salt is selected from carbonate, phosphate, strontium, and fluoride salts.

3. The composition as described in claim 1, wherein said organic salt is selected from citrate, malate, lactate, and gluconate salts.

4. The composition as described in claim 1, wherein said organic acid is selected from citric acid, malic acid, lactic acid, and gluconic acid.

5. The composition as described in claim 1, wherein said organic compound is selected from the group consisting of biological fluids and components, water-soluble or miscible organic polyols, drugs, aminoacids, and proteins.

6. The composition as described in claim 1, which further comprises a water-soluble or miscible organic polyol, including sugar-polyol, saccharide-polyol and glycol, selected from the group consisting of glycerol, mannitol, sorbitol, ethylene glycol oligomers, propylene glycol oligomers, saccharose, fructose, glucose, and maltose.

7. The composition as described in claim 1, which further comprises glucosamine and/or histidine.

8. The composition as described in claim 1, which further comprises a strontium containing compound.

9. The composition as described in claim 1, which further comprises a carbonate containing compound.

10. The composition as described in claim 1, which further comprises a fluoride containing compound.