Compounds for therapy and diagnosis
First Claim
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1. A transition metal complex of formula (I) or salts thereof:
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Abstract
The present invention relates to a transition metal complex represented by Formula (I) or salts thereof, or to a ligand represented by Formula (H) or salts thereof, wherein X represents a transition metal, preferably Pt, and methods for their use and preparation. In particular, the invention relates to compounds which may possess useful therapeutic activity in treating amyloid diseases, and in particular, Alzheimer'"'"'s disease. The invention also relates to the use of these compounds in methods of therapy, and diagnosis, and the manufacture of medicaments as well as compositions containing these compounds.
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Citations
29 Claims
- 1. A transition metal complex of formula (I) or salts thereof:
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3. A transition metal complex of formula (I′
- ) or a salt thereof;
- View Dependent Claims (4, 5, 6)
- ) or a salt thereof;
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14. A platinum complex of formula (I″
- ) or a salt thereof;
- View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28)
- ) or a salt thereof;
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26. A method for treating Alzheimer disease including the step of administering to a patient in need thereof a transition metal complex of formula (I) or a pharmaceutically acceptable salt thereof;
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27. A method of diagnosing Alzheimer disease comprising:
(i) administering a detectable quantity of a transition metal complex of formula (I) or a salt thereof to a patient;
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29. A transition metal complex selected from the following:
Specification