Phosphonate fluorescent dyes and conjugates
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Abstract
Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates.
53 Citations
12 Claims
- 1. A fluorescent dye reagent having the formula:
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10. A fluorescent dye reagent having the formula:
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Fl-P1wherein Fl is a fluorescent dye component; and P1 is functionalized phosphonate group having the formula; - View Dependent Claims (11)
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12. A conjugated substance comprising one or more phosphonylated fluorescent dyes coupled through a linking group to a conjugated substance or biological agent, wherein the phosphonylated fluorescent dyes have structures selected from the group of consisting of:
Specification