Treatment devices and methods with extending elements

• US 8,389,791 B2
• Filed: 04/18/2011
• Issued: 03/05/2013
• Est. Priority Date: 05/29/2003
• Status: Active Grant

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Inventors: Gurtner, Geoffrey C., Dauskardt, Reinhold H., Longaker, Michael T., Yock, Paul
• Primary Examiner(s): Brown, Michael
• Assistant Examiner(s): HAWTHORNE, OPHELIA ALTHEA
• Application Number:
  US13/089,104
• Publication Number:
  US 20120046591A1
• Time in Patent Office: 687 Days
• Field of Search: 602 41- 59, 606213-216, 128888-889, 206/570, 424443-449, 523/105, 523/111, 523/122
• US Class Current: 602/41
• CPC Class Codes: A61F 13/00051 Accessories for dressings
• CPC Class Codes: A61F 13/00059 provided with visual effects, e.g. printed or colored
• CPC Class Codes: A61F 13/0233 characterised by the oclusive layer skin contacting layer
• CPC Class Codes: A61F 13/0243 characterised by the properties of the skin contacting layer, e.g. air-vapor permeability
• CPC Class Codes: A61F 2013/00123 with elastic indicator
• CPC Class Codes: A61F 2013/00127 fixation means
• CPC Class Codes: A61F 2013/00153 coloured or with decoration pattern or printing
• CPC Class Codes: A61F 2013/00182 with transparent part
• CPC Class Codes: A61F 2013/0028 applying of mechanical pressure; passive massage
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 47/64 Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent peptidic linkers A61K47/65
• CPC Class Codes: A61K 47/67 Enzyme prodrug therapy, e.g. gene directed enzyme drug therapy [GDEPT] or VDEPT
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C07K 5/0606 the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
• CPC Class Codes: C07K 5/06113 Asp- or Asn-amino acid
• CPC Class Codes: C07K 5/0806 the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
• CPC Class Codes: C07K 5/081 the side chain containing O or S as heteroatoms, e.g. Cys, Ser
• CPC Class Codes: C07K 5/1008 the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
• CPC Class Codes: C07K 7/02 Linear peptides containing at least one abnormal peptide link
• CPC Class Codes: C07K 9/005 containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
• CPC Class Codes: G01N 2333/95 : Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
• CPC Class Codes: G01N 2500/00 : Screening for compounds of potential therapeutic value
• CPC Class Codes: G01N 33/57407 : Specifically defined cancers
• CPC Class Codes: G01N 33/57419 : of colon

Abstract

Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound'"'"'s mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

Claims

1. A device configured for reducing exogenous or endogenous stress experienced by skin tissue comprising:

a treatment device comprising a sheet and a securing element configured to removably secure the sheet to a skin surface, wherein the treatment device has a first tensile stressed configuration, and a second relaxed configuration wherein the treatment device is configured to stress tissue to reduce stress experienced by skin tissue at or near the treatment device; and

an extending element configured to be extended to form the first tensile stressed configuration prior to application to a skin surface and configured to be released to form the second relaxed configuration;

wherein the extending element is a spring element.

2. The device of claim 1, wherein the securing element comprises an adhesive.

3. The device of claim 2, wherein the adhesive has a T-Peel release force test value greater that about 125 kg/m.

4. The device of claim 3, wherein the T-Peel release force test value of the adhesive is at least about 286 kg/m.

5. The device of claim 2, wherein the adhesive has a blunt probe tack test value that is greater than about 0.45 kg.

6. The device of claim 5, wherein the adhesive has a blunt probe tack test value that is at least about 0.5 kg.

7. The device of claim 2, wherein the adhesive is a pressure sensitive adhesive selected to minimize creep properties when applied to a skin surface.

8. The device of claim 1, wherein the treatment device has a non-uniform thickness.

9. The device of claim 8, wherein the treatment device comprises at least one tapered edge.

10. The device of claim 1, wherein the extending element is configured to maintain the treatment device in the first tensile stressed configuration until it is released.

11. The device of claim 1, wherein the first tensile stressed configuration is mechanically induced by the extending element when it is extended.

12. The device of claim 1, wherein the first tensile stressed configuration has a strain of at least about 10% relative to the relaxed configuration.

13. The device of claim 1, wherein the first tensile stressed configuration has a strain of at least about 20% relative to the relaxed configuration.

14. The device of claim 1, wherein the first tensile stressed configuration is configured to be adjusted to accommodate different ranges of motion.

15. A method for reducing endogenous or exogenous stress experience by skin tissue comprising:

providing a device having a body configured to be removably secured with a securing element to a skin surface; and

an extending element configured to apply tensile stress to the device;

before securing the device to the skin surface, applying a tensile stress to the device using the extending element to form a tensile stressed configuration;

securing the device to the skin surface of a patient while the device is in the tensile stressed configuration;

removing at least some of the tensile stress from the device using the extending element to adopt a partially relaxed configuration that is adapted to stress tissue at or external to the securing element.

16. The method of claim 15, wherein the securing element comprises an adhesive.

17. The method of claim 16, wherein the adhesive is selected to minimize creep properties when the device is applied with the adhesive to a skin surface.

18. The method of claim 15, wherein removing the tensile stress from the device comprises releasing the extending element with respect to the device.

19. The method of claim 15, wherein the extending element comprises a spring element.

20. The method of claim 15, wherein removing at least some of the tensile stress from the device is further adapted to pull tissue underneath the device inward to reduce stress at a skin wound.

21. The method of claim 15, wherein removing at least some of the tensile stress from the device is further adapted to reduce stress at a wound site to a stress level that is lower than stress experienced by unscarred skin of the patient.

22. The method of claim 15, wherein the extending element comprises a shape memory material and wherein removing at least some of the tensile stress from the device comprises transforming the shape memory material from a first state to a second state.

23. The method of claim 15, wherein forming the tensile stressed configuration comprises straining the device by at least about 10%.

24. The method of claim 15, wherein forming the first tensile stressed configuration comprises straining the device by at least about 20%.

25. The method of claim 15, wherein forming the first tensile stressed configuration comprises straining the device by at least about 40%.

26. A method for reducing endogenous or exogenous stress experience by skin tissue comprising:

providing a device having a body configured to be removably secured with a securing element to a skin surface; and

an extending element configured to be extended to form a tensile stressed configuration of the device and to be released from the device to remove the tensile stress from the device, wherein the device is configured to adopt a second relaxed configuration, stressing tissue at or external to the securing element.