System and method for cardiac resynchronization therapy with optimization of effort-based rate-responsive pacing

• US 8,391,976 B2
• Filed: 11/23/2010
• Issued: 03/05/2013
• Est. Priority Date: 11/23/2009
• Status: Active Grant

• Current Assignee: Sorin CRM USA (MicroPort Scientific Corp.)
• Original Assignee: Sorin CRM USA (MicroPort Scientific Corp.)
• Inventors: Limousin, Marcel
• Primary Examiner(s): Patel, Niketa
• Assistant Examiner(s): Hankins, Lindsey G
• Application Number:
  US12/953,090
• Publication Number:
  US 20110125209A1
• Time in Patent Office: 833 Days
• Field of Search: 607 4- 38, 607119-132, 600373-375, 600449-450, 600481-503, 600508-528
• US Class Current: 607/17
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

An active implantable medical device for cardiac resynchronization therapy with effort based rate-responsive pacing is described. The device calculates a rate-responsive stimulation frequency based on output signal of an effort sensor between a base frequency (f_base) and a maximum frequency (f_max). The device determines a target stimulation frequency based on the difference between a first frequency and the maximum frequency (f_max). The first frequency is the higher frequency of the base frequency (f_base) and the spontaneous frequency of the patient. The device calculates a stimulation frequency that has an immediate increase in the pacing rate from the higher of the initial value of the current stimulation frequency, or the spontaneous frequency to the target stimulation frequency, within a predetermined time, or a predetermined number of cardiac cycles. A plurality of consecutive effort zones (Z1-Z4) is defined over the extent of the dynamic range of the output signal of the effort sensor.

Claims

1. An active implantable medical device for treating a heart failure condition with cardiac resynchronization therapy (CRT) and/or with synchronized stimulation, comprising:

an effort sensor providing an output signal representative of a current level of a patient'"'"'s effort; and

a CRT pacemaker having electrodes configured to determine a spontaneous frequency (f_sp) of a patient in the presence of a sinus rhythm and control logic configured to detect a beginning of the patient'"'"'s effort from the output signal, stimulation frequency varying between a base frequency (f_base) and a maximum frequency (f_max) according to the output signal, and selectively delivering stimulation pulses according to said effort stimulation frequency, said control logic selectively delivering stimulation pulses for CRT via incrementing said delivered pulse stimulation frequency by;

determining a target frequency based on a difference between a first frequency and the maximum frequency (f_max), wherein the first frequency is the higher frequency of the base frequency (f_base) and the spontaneous frequency (f_sp); and

increasing, in response to a detection of the beginning of the patient'"'"'s effort, the stimulation frequency from an initial value or the spontaneous frequency to said target frequency in a predetermined time period corresponding to the time period of no more than four cardiac cycles.

2. The device of claim 1, wherein the output signal of the effort sensor has a dynamic range, the control logic being provided and configured to define a plurality of consecutive effort zones corresponding to the dynamic range of the output signal of the effort sensor, determining when the output signal of the effort sensor increases from a preceding effort zone to a consecutive effort zone, and wherein incrementing said delivered pulse stimulation frequency determines, separately for each consecutive effort zone, said target frequency and an increase of the delivered stimulation frequency to said determined target frequency, the determined target frequency of each consecutive effort zone being based on the difference between the target frequency of the preceding effort zone and the maximum frequency (f_max).

3. The device of claim 2, wherein said plurality of consecutive effort zones are defined by an equal division of the dynamic range of the output signal of the effort sensor.

4. The device of claim 2, further comprising means for updating the dynamic range of the output signal of the effort sensor, and redefining the corresponding plurality of consecutive effort zones to the updated dynamic range.

5. The device of claim 1, wherein said control logic is configured to determine the target frequency determines a percentage of the difference between the first frequency and the maximum frequency (f_max).

6. The device of claim 5, wherein said percentage is 50%.