Chondrocyte therapeutic delivery system
First Claim
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1. A method for expressing a therapeutic agent in a subject using a genetically altered chondrocyte, comprising:
- providing a genetically altered chondrocyte, wherein the genetically altered chondrocyte has been altered to express a therapeutic agent;
implanting a biocompatible substrate comprising the genetically altered chondrocyte into a target region of the subject, wherein the target region is in an atypical chondrocyte environment, wherein the genetically altered chondrocyte becomes a structural component of neither the target region nor the atypical chondrocyte environment surrounding the target region; and
expressing the therapeutic agent in the target region at a level higher than the baseline level of said therapeutic agent in the target region so as to modify the environment surrounding the target region.
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Abstract
Methods and compositions for producing therapeutic agents using chondrocytes are provided. The genetically engineered chondrocytes can be used to express the therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.
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9 Claims
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1. A method for expressing a therapeutic agent in a subject using a genetically altered chondrocyte, comprising:
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providing a genetically altered chondrocyte, wherein the genetically altered chondrocyte has been altered to express a therapeutic agent; implanting a biocompatible substrate comprising the genetically altered chondrocyte into a target region of the subject, wherein the target region is in an atypical chondrocyte environment, wherein the genetically altered chondrocyte becomes a structural component of neither the target region nor the atypical chondrocyte environment surrounding the target region; and expressing the therapeutic agent in the target region at a level higher than the baseline level of said therapeutic agent in the target region so as to modify the environment surrounding the target region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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