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Once daily formulations of tetracyclines

DC CAFC
  • US 8,394,405 B2
  • Filed: 12/17/2010
  • Issued: 03/12/2013
  • Est. Priority Date: 04/07/2003
  • Status: Expired due to Term
First Claim
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1. An oral pharmaceutical composition comprising about 40 mg of total doxycycline, which at a once-daily dosage will give steady state blood levels of doxycycline of a minimum of 0.1 μ

  • g/ml and a maximum of 1.0 μ

    g/ml, wherein the composition consists of 70 to 80 percent of the doxycycline formulated as an immediate release (IR) formulation and 20 to 30 percent of the doxycycline formulated as a delayed release (DR) formulation.

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