Method of characterizing particles

• US 8,395,398 B2
• Filed: 04/23/2010
• Issued: 03/12/2013
• Est. Priority Date: 04/24/2009
• Status: Active Grant

• Current Assignee: Beckman Coulter Incorporated (Danaher Corporation)
• Original Assignee: Beckman Coulter Incorporated (Danaher Corporation)
• Inventors: Xu, Renliang, Yang, Yiming
• Primary Examiner(s): Assouad, Patrick
• Assistant Examiner(s): BROWN, LAMARR A
• Application Number:
  US12/766,057
• Publication Number:
  US 20100271053A1
• Time in Patent Office: 1,054 Days
• Field of Search: 324/699, 324/71.4, 324/71.1, 377/11, 377/12, 702/21, 702/26, 702/29
• US Class Current: 324/699
• CPC Class Codes: G01N 15/13 Details pertaining to apertures
• CPC Class Codes: G01N 2015/1024 Counting particles by non-optical means
• CPC Class Codes: G01N 2015/1029 Particle size

Abstract

Mixtures containing homogeneously-sized particles with a minimum concentration of agglomerates or larger particles are desired in various manufacturing processes such as, for example, in the manufacture and use of chemical mechanical polishing slurries, food emulsions, pharmaceutical products, paints, and print toner. The method disclosed herein provides these industries with an accurate and efficient method of screening such mixtures for such agglomerates and large particles. The method generally includes preparing a suspension of the mixture in an electrolyte, wherein the suspension includes a specified concentration of small particles per unit of electrolyte. The method further includes passing the prepared suspension, and a plurality of the particles therein, through an aperture of a device capable of characterizing particles according to the Coulter principle to obtain data on the particles. Still further, the method includes deriving a particle size distribution of the large particles from the obtained data. The suspension includes at least one small particle per aperture volume. The large particles have an average diameter that is at least five times greater than the average diameter of the small particles. The aperture has a diameter that is (i) at least 50 times greater than the average diameter of the small particles, and (ii) about 1.2 times greater than the average diameter of the large particles to less than about 50 times greater than the average diameter of the large particles.

Claims

1. A method of characterizing large particles present among a mixture of particles more highly concentrated with small particles, the method comprising:

(a) preparing a suspension of the mixture in an electrolyte;

(b) passing the prepared suspension, and a plurality of the particles therein, through an aperture of a device capable of characterizing particles according to the Coulter principle to obtain data on the particles; and

,

(c) deriving a particle size distribution from the obtained data, wherein the suspension comprises at least one small particle per aperture volume, and wherein the large particles have an average diameter that is at least five times greater than the average diameter of the small particles, and the aperture has a diameter that is (i) at least 50 times greater than the average diameter of the small particles, and (ii) about 1.2 times greater than the average diameter of the large particles to less than about 50 times greater than the average diameter of the large particles.

2. The method of claim 1, wherein the suspension comprises at least 30 small particles per aperture volume.

3. The method of claim 1, wherein the suspension comprises at least 400 small particles per aperture volume.

4. The method of claim 1, wherein the suspension comprises at least 3100 small particles per aperture volume.

5. The method of claim 1, wherein the large particles have an average diameter that is at least 10 times greater than the average diameter of the small particles.

6. The method of claim 1, wherein the large particles have an average diameter that is at least 20 times greater than the average diameter of the small particles.

7. The method of claim 1, wherein the large particles have an average diameter that is at least 50 times greater than the average diameter of the small particles.

8. The method of claim 1, wherein the aperture has a diameter that is about 5 to about 40 times greater than the average diameter of the large particles.

9. The method of claim 1, wherein the aperture has a diameter that is about 10 to about 30 times greater than the average diameter of the large particles.

10. The method of claim 1, wherein the aperture has a diameter that is about 15 to about 25 times greater than the average diameter of the large particles.

11. The method of claim 1, wherein the large particles comprise first and second collections of large particles, and wherein the first collection of large particles has an average diameter that is at least five times greater than the average diameter of the small particles, and the second collection of the large particles has an has an average diameter that is at least 2.5 times greater than the average diameter of the first collection of large particles.

12. The method of claim 11, wherein the average diameter of the second collection of the large particles is at least 5 times greater than the average diameter of the first collection of large particles.

13. The method of claim 11, wherein the average diameter of the second collection of the large particles is at least 10 times greater than the average diameter of the first collection of large particles.

14. The method of claim 1, wherein a concentration of small particles is at least ten times greater than a concentration of large particles.

15. The method of claim 1, wherein a concentration of small particles is at least 1,000 times greater than a concentration of large particles.

16. The method of claim 1, wherein a concentration of small particles is at least 100,000 times greater than a concentration of large particles.